3881 papers
This study establishes a comprehensive cross-tissue single-cell and multiomics atlas in mice to reveal how cold exposure drives tissue-selective immunometabolic remodeling, highlighting a specific cold-associated macrophage subpopulation in the lung regulated by the multiomics node Chil3.
This study of the prickly pear phyllosphere microbiome across Texas reveals that seasonal shifts and ecoregion significantly influence microbial diversity and network structure, suggesting the absence of a stable, consistent core community due to the harsh environmental conditions and dynamic interactions between generalist and specialist taxa.
This study demonstrates that both APOL6 overexpression and 5-azacytidine treatment independently remodel the lipid metabolic landscape in triple-negative breast cancer cells by promoting neutral lipid accumulation and suppressing key biosynthetic pathways, revealing shared metabolic vulnerabilities despite their distinct mechanisms.
This study utilizes shotgun metagenomic sequencing of 31 Ethiopian wolves to reveal that host ontogeny, rather than pack membership, significantly shapes gut microbiome composition and pathogen burden, with adults exhibiting higher cumulative abundances of potentially pathogenic bacteria than subadults.
This prospective multiomic study reveals that while a gluten-free diet partially restores the fecal bacteriome in children with celiac disease, it does not fully normalize it, and specific bacterial taxa are significantly correlated with serum PFAS levels and disease-specific autoantibodies.
This study presents a comprehensive benchmark of 20 state-of-the-art cell type annotation methods across diverse spatial transcriptomics technologies and biological contexts, revealing that while tools like scANVI, Seurat, and TACCO perform well overall, accurate fine-grained and dynamic state annotation remains challenging and highly context-dependent, highlighting the need for future methods to better handle open-set recognition, spatial integration, and rare cell populations.
This study demonstrates that free-ranging cats in a managed urban park in Brazil exhibit persistent predatory activity on diverse wildlife, with interactions concentrated near human feeding stations, suggesting that food provisioning may inadvertently increase predation opportunities and necessitate integrating feeding practices into urban wildlife conservation strategies.
This study demonstrates that the minimal two-subunit ESCRT-III/Vps4 system from Asgard archaea recapitulates eukaryotic-like membrane remodeling capabilities, utilizing distinct assembly modes to deform and constrict membranes across both nanoscale and micron-scale dimensions.
Genomic analysis of *Fusarium oxysporum* isolates from Türkiye reveals that while the SIX effector repertoire is strongly predicted by phylogenetic lineage rather than host origin, the specific *Avr2* race genotype cannot be inferred from core-genome distance or lineage.
This study marks the first successful isolation of viable *Bartonella* species from wild rodents and a naturally infected *Neotyphloceras* flea in Chile, confirming the circulation of a putative novel species and reinforcing the role of these rodents and fleas as reservoirs and vectors within a One Health framework.