🧬 Category

q-bio

3881 papers

🧬 biology

First in vivo evaluation of the radiolabelled Hsp90 inhibitor [11C]Onalespib for cancer and brain PET imaging

This study presents the first preclinical evaluation of the radiolabelled Hsp90 inhibitor [¹¹C]Onalespib, demonstrating its high purity and specific binding to Hsp90 in vitro and in tumour tissues, while revealing limitations such as rapid metabolic degradation, variable tumour uptake, and negligible brain penetration that necessitate further optimization for clinical PET imaging.

Valeria Narykina, Romy Cools, Niels Van Winnendael, Koen Vermeulen, Guy Bormans, Ludovic Le Saux2026-08-28
🧬 biology

Single-cell analysis reveals shared and stage-specific features of the human skin response in primary and secondary syphilis lesions

By integrating single-cell transcriptomics with tissue analyses of human syphilis lesions, this study reveals that while robust immune activation occurs in both primary and secondary stages, impaired B cell affinity maturation and specific immune cell dynamics contribute to the pathogen's ability to evade effective humoral immunity.

Justin Radolf, Xuan Yi, Kelly Hawley, Yan Zhang, Xiaoyuan Xie, Jun Xian, Haobin Chen, Zhijia Li, Litian Zhang, Yinbo Jia (…)2026-08-28
🧬 biology

Integrative genome and transcriptome mining identifies a diverse repertoire of cyclooxygenase/prostaglandin- endoperoxide synthase-like candidates in Porifera

By integrating extensive genomic and transcriptomic data, this study identifies a diverse repertoire of cyclooxygenase/prostaglandin-endoperoxide synthase-like candidates in Porifera, challenging previous assumptions of their absence and suggesting the enzyme lineage originated in the last common ancestor of sponges, cnidarians, and bilaterians.

Sebastiano Scibelli2026-08-28
🧬 biology

Selective Segregation of Damaged Molecules Is the Universal Rule of Cellular Rejuvenation, and Centriolar Retention in Stem Cells Is Its Exception

This paper argues that while the universal rule of cellular rejuvenation involves selectively segregating damaged molecules to one daughter cell, the retention of older, damage-accumulating centrioles in self-renewing stem cells constitutes a singular exception that drives organismal aging, a mechanism absent in non-regenerating organisms like *C. elegans* and post-mitotic mammalian tissues.

Jaba Tqemaladze2026-08-28
🧬 biology

Metagenomic Study on the Variable Influence of Soil Microbiomes on Oryza sativa Seedling Microbiome Across Different Cultivated Soils

This metagenomic study utilizes 16S and 18S rRNA amplicon sequencing to demonstrate that soil type significantly shapes the bacterial and fungal composition of *Oryza sativa* seedlings, revealing distinct microbial profiles and greater root diversity in response to varying soil conditions.

REMYA UNNIKRISHNAN, Priya V.K, Padinjarakavil Soumya, Jayachandran K, Radhakrishnan E.K2026-08-28
🧬 biology

In-Silico Reclassification of TP53 Variants of Uncertain Significance (VUS) Integrating Ensemble Predictors, Evolutionary Conservation, and 3D Structural Dynamics

This study presents a multi-layered computational pipeline that integrates ensemble pathogenicity scores, evolutionary conservation, and 3D structural dynamics to reclassify 625 TP53 variants of uncertain significance, successfully identifying high-confidence pathogenic candidates that meet specific ACMG criteria for prioritization in functional validation.

Anahita Gupta2026-08-28
🧬 biology

WITHDRAWN: MicroRNA-32-5p Inhibits Metastasis By Directly Targeting VPS4B and Increases Sensitivity to Dihydroartemisinin in Neuroblastoma

This preprint, titled "MicroRNA-32-5p Inhibits Metastasis By Directly Targeting VPS4B and Increases Sensitivity to Dihydroartemisinin in Neuroblastoma," has been withdrawn by the authors on August 28, 2026, due to an unresolved authorship dispute and should not be cited.

Lina Chen, Hui Liu, Zhongyuan Zheng, Xi Wang, Shuiqing Qu, Yuanmin Yang, Shuoqiu Deng, Yu Zhang, Tuo Liu, Honghua Cui, Y (…)2026-08-28
🧬 biology

Emotion reconfigures neuronal coordination across brains to control social choice

This study reveals that emotions dynamically reconfigure cell-type-specific brain-to-brain coupling in the anterior cingulate cortex—specifically switching from pyramidal to somatostatin neuron coordination under stress—to causally control social choice, a mechanism that is conserved across mice and humans.

Francesco Papaleo, Federica Antonelli, Anna Monai, Fabrizio Bernardi, Atesh Koul, Nicola Marie Engel, Ilaria Carta, Fran (…)2026-08-28
🧬 biology

WTR: A Toolkit for Functional Anterograde Transsynaptic Circuit Mapping

The authors developed WTR, a versatile AAV-delivered fusion protein toolkit that enables cell-type-specific anterograde transsynaptic labeling, recording, and manipulation of downstream neurons to functionally map neural circuits, as demonstrated by its application in dissecting thermoregulatory and stress-response pathways in the hypothalamus.

Tongfei Wang, Chao Chen, Ruogu Liu, Aijia Yi-Luo, Xiaoyan Cao, Jitao Hu, Shikang Guan, Si-Yuan Chang, Xiaoli Cui, Wei Zh (…)2026-08-28