🧬 Category

q-bio

1625 papers

🧬 biology

The clinical and molecular spectrum of AGO2-associated Lessel-Kreienkamp neurodevelopmental syndrome

This study expands the clinical and molecular understanding of Lessel-Kreienkamp syndrome by characterizing 45 new individuals with AGO2 variants, revealing a multisystemic neurodevelopmental disorder driven by diverse structural perturbations that disrupt specific AGO2 functions—including miRNA binding, P-body assembly, and phosphorylation-dependent turnover—thereby linking distinct molecular mechanisms to phenotypic variability.

Debora Tibbe, Christina Kiel, Olena Ielesicheva, Kerstin Robles de Maruri, Helia Mahboobi, Joschka Züghart, Hans-Hinrich (…)2026-07-02
🧬 biology

GeneRhythm uncovers gene expression rhythms that shape the dynamic transcriptional landscape in single-cell omics

The paper introduces GeneRhythm, a novel framework that reformulates single-cell gene expression analysis in the time-frequency domain to uncover rhythmic regulatory programs and disease-relevant dynamics that are invisible to conventional time-domain approaches.

Jun Ding, Xiuhui Yang, Yiming Jia, Braeden Giles, Yumin Zheng, Jingtao Wang, Kailu Song, Bowen Zhao, Yasmin Jolasun, Vis (…)2026-07-02
🧬 biology

Gut microbiota of insectivorous bats in Japan harbor Chlamydophila psittaci and Shiga toxin-producing Escherichia coli: host species and location shape community structure

This study characterizes the gut microbiota of three insectivorous bat species in Japan, revealing that both host species and sampling location significantly shape community composition while identifying the first detection of *Chlamydophila psittaci* alongside other pathogens like *Bacillus cereus* and Shiga toxin-producing *Escherichia coli*, thereby highlighting the importance of wildlife microbiome surveillance for One Health.

Rosalia Mwongeli Makau, Bett Evalyne Chepkirui, Ishara Uhanie Perera, Takashi Shimizu, Masanori Hashino, Hiroshi Shimoda (…)2026-07-02
🧬 biology

Cell-Size-dependent of bacterial communities antibiotic resistome profiles and risk assessment in a river: A metagenomic analysis

This metagenomic study reveals that while small-sized (0.1–0.45 µm) and large-sized (>0.45 µm) river bacteria exhibit distinct antibiotic resistance gene compositions and host communities, they ultimately pose comparable antimicrobial resistance risks, highlighting the significant and previously overlooked role of small-sized bacteria in environmental resistomes.

Pengfei Yang, Jiaxian yao, Yuehua Zhang, Yongzhen Zhao, Zening Wang, Shuhan Li, Fangzhou Gao, Guannan Mao, Shuai Zhang (…)2026-07-02
🧬 biology

Performance of a fine-scale positioning acoustic telemetry array in a deep freshwater ecosystem

This study evaluates a fine-scale positioning acoustic telemetry array in a deep freshwater ecosystem, finding that while detection efficiency varies with tag power, receiver spacing, and temperature, the system remains effective for accurate animal positioning with receivers spaced 400–800 meters apart.

Benjamin L. Hlina, Aaron T. Fisk, Dale M. Webber, Neil Rooney, Timothy B. Johnson2026-07-02
🧬 biology

Early-life stress shapes tissue-specific gut-brain metabolomic and microbial profiles in laying hens

This study demonstrates that early-life stress in laying hens induces persistent, tissue-specific metabolic and microbial reorganization along the gut–brain axis in adulthood, characterized by localized lipid and redox alterations in the ileum and brain while systemic plasma profiles remain largely unaffected.

Annemarie J.W. Mens, Ingrid C. de Jong, Soumya K. Kar, René P. Kwakkel, Edoardo Zaccaria2026-07-02
🧬 biology

Comparative Ion Channel Transcriptomes of NK1R and Somatostatin Neurons in the preBötzinger Complex of the Ventrolateral Medulla

This study utilizes single-nucleus RNA sequencing to characterize the distinct ion channel transcriptomes of Tacr1+ and Sst+ neurons in the preBötzinger Complex, revealing that Tacr1+ neurons possess a unique molecular signature involving coordinated upregulation of TRPC5, NALCN, and specific neuromodulatory receptors that likely underpin their critical role in generating respiratory rhythms.

Hemalatha Bhagavan, Aguan D. Wei, Luiz M. Oliveira, Jan-Marino Ramirez2026-07-02
🧬 biology

Host induced microRNA hsa-miR-643 promotes Mycobacterium tuberculosis survival inside macrophages by downregulating Gins2

This study demonstrates that the host microRNA hsa-miR-643 promotes *Mycobacterium tuberculosis* survival within macrophages by directly targeting and downregulating Gins2, thereby inhibiting apoptosis and suggesting hsa-miR-643 as a potential therapeutic target for tuberculosis.

Garima Kumari, Ruchi Verma, Mohd Mustkim Ansari, Rajendra Kumar Dhuriya, Gunjan Tripathi, Bhupendra N Singh2026-07-02
🧬 biology

Genomics and transcriptomics of nervous system from Rhodnius prolixus, and its modulation after a blood meal in an immature stage

This study utilizes improved genomic data and transcriptomic analysis to characterize the nervous system of the Chagas disease vector *Rhodnius prolixus*, revealing that blood feeding in fifth instar nymphs triggers a widespread downregulation of genes involved in physiological processes, suggesting a shift from a starved, responsive state to a post-feeding, less responsive condition.

Natalia Capriotti, Lucila Traverso, Jose Manuel Latorre Estivalis, Ivana Sierra, Juan P. Ianowski, Sheila Ons2026-07-02
🧬 biology

Molecular dynamics simulation of the effect of initial temperature and initial pressure on thermal behavior and cavitation dynamics in tumor tissue

This study employs molecular dynamics simulations to demonstrate that while initial temperature and pressure variations (280–310 K and 0–2 bar, respectively) do not alter the saturation or equilibrium temperatures of a tumor tissue model, they significantly influence structural expansion and thermal conductivity through non-monotonic trends, with optimal thermal and structural properties observed at 1 bar due to a balance between interatomic spacing and atomic mobility.

Mohsen shafiee, Ghanbarali Sheikhzadeh2026-07-02