q-bio papers | Gist.Science

Effects of rearing density on larval susceptibility to Bacillus thuringiensis and Beauveria bassiana in Spodoptera exigua

This study demonstrates that *Spodoptera exigua* larvae reared at moderate densities exhibit enhanced immune competence and survival against *Bacillus thuringiensis* and *Beauveria bassiana* compared to solitary or highly crowded individuals, providing evidence for density-dependent prophylaxis and highlighting the need to consider population density in biocontrol strategies.

Muhammad Taimur, Hui-Min Gu, Su-Wan Jiang, Zi-Cheng Fan, Zhi-Wei Chen, Hai-Long Kong2026-08-28

🧬 biology

A wearable multi-task prefrontal functional near-infrared spectroscopy methodology for studying mild traumatic brain injury: a human-subject pilot implementation

This paper presents a pilot implementation of an integrated wearable multi-task prefrontal fNIRS methodology for studying mild traumatic brain injury, documenting the technical workflow and demographic challenges while acknowledging that the study's limitations prevent definitive conclusions regarding diagnostic accuracy, tolerability, or the incremental value of fNIRS beyond demographics.

Chia-Wei Sun, Yi-Hua Huang, Chun-Yeh Wang, Chi-Chieh Shih, Sanford P. C. Hsu2026-08-28

🧬 biology

Enhanced chromatin compaction is associated with de novo expression of a nuclear microprotein, global loss of H3 acetylation and local transcriptional changes in retinal rod photoreceptors

This study reveals that aging in mouse rod photoreceptors drives global chromatin compaction and a loss of histone H3 acetylation, mediated by the de novo expression of a microprotein (Gm7239) that inhibits histone acetylation, ultimately leading to local transcriptional changes linked to age-related macular degeneration.

Anand Swaroop, Claire Marchal, Mohita Gaur, Anjani Kumari, Sonali Mohan, Matthew Brooks, Catherine Jaeger, Jayshree Adva (…)2026-08-27

🧬 biology

Neural synchronization drives statistical learning through temporal and content predictions

This study demonstrates that neural synchronization during statistical learning not only sustains temporal and content predictions beyond stimulus offset but also actively evaluates incoming information against prior context to shape learning outcomes.

Lorenzo Titone, Lars Meyer2026-08-27

🧬 biology

MetaPilot: genome-aware adaptive search-space refinement for unified DDA and DIA metaproteomics

MetaPilot is a genome-aware workflow that utilizes conserved marker-protein evidence to dynamically refine search spaces for both DDA and DIA metaproteomics, thereby significantly increasing peptide identification depth and enabling genome-resolved functional analysis compared to existing methods.

Kai Cheng, Daniel Figeys2026-08-27

🧬 biology

DynaMate: An Autonomous Agent for Protein-Ligand Molecular Dynamics Simulations

The paper introduces DynaMate, an autonomous multi-agent framework that leverages large language models to fully automate complex protein-ligand molecular dynamics workflows, significantly reducing setup time and error resolution while demonstrating high success rates across hundreds of diverse biomolecular systems.

Cassandra Masschelein, Salomé Guilbert, Jeremy Goumaz, Bohdan Naida, Ursula Rothlisberger, Philippe Schwaller2026-08-27

🧬 biology

A Sensitive and Specific One-step TaqMan RT-qPCR Assay for Rapid Detection of Enterovirus C99

This study developed and validated a rapid, sensitive, and specific one-step TaqMan RT-qPCR assay targeting the VP1 gene for the efficient detection and surveillance of the emerging Enterovirus C99, demonstrating superior performance over conventional methods in both laboratory and wastewater samples.

Jingyi Song, Wei Zhang, Baoqin Liu, Baisheng Li, Mengmeng Liu, Yao Qin, Yun Zhang2026-08-27

🧬 biology

Transcriptomic Consequences of CD74 Knockout in Raji and Meljuso Tumor Cells

This study demonstrates that CD74 knockout triggers extensive, context-dependent transcriptional reprogramming in Raji and Meljuso tumor cells, revealing its broader role as a regulator of cellular homeostasis and immune signaling beyond its canonical function in antigen presentation.

Shivani Tyagi, Manoj Kumar B S, Oddmund Bakke, Swarupa Panda, Niladri Bhusan Pati2026-08-27

🧬 biology

Age-related Abnormalities in the Development of Brain White Matter Fiber Networks in Patients with Autism Spectrum Disorders

This cross-sectional study of 146 ASD and 98 typically developing individuals aged 6–18 reveals that while whole-brain white matter network topology undergoes dynamic age-related development in both groups, specific regional connectivity and nodal properties exhibit potential group differences, though these findings warrant cautious interpretation due to sample limitations and lack of multiple comparison correction.

Gang-Qiang Han, Yan-Qing Guo, Siu-ching Kat, Hui Wang, Xiao-Yun Gong, Zeng-Hui Ma, Yu-Lu Yang, Ting-Ni Yin, Li-Yang Zhao (…)2026-08-27

🧬 biology

Functional interaction between D2-like dopamine and μ-opioid receptors in the hippocampal dentate gyrus modulates inflammatory pain in male rats

This study demonstrates that D2-like dopamine and μ-opioid receptors in the hippocampal dentate gyrus functionally interact to modulate inflammatory pain in male rats, suggesting this neural circuit as a promising target for opioid-sparing analgesic strategies.

Mohanna Akbarin Mayvani, Sara Arvand, Farzaneh Nazari-Serenjeh, Roghayeh Mozafari, Abbas Haghparast2026-08-27

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