🧬 Category

q-bio

1625 papers

🧬 biology

Natural Phenolic Acids Modulate Memory and Anxiolytic Behavior in Adult Zebrafish (Danio Rerio): Serotonergic Involvement, Oxidation-Dependent Activity, Quantum Calculations, and Molecular Docking Highlight Sinapic acid

This study demonstrates that natural phenolic acids, particularly sinapic acid, exert dose-dependent anxiolytic and memory-preserving effects in adult zebrafish through serotonergic mechanisms and oxidation-dependent activity, as confirmed by behavioral assays, molecular docking, and quantum calculations.

Thaís Rocha Cavalcante, Jéssica Bezerra Maciel, Amanda Maria Barros Alves, Joilna Alves Silva, Jacilene Silva, Tainá Sou (…)2026-07-02
🧬 biology

The Impact of Obesity on Appetite Regulation During Nutritional Ketosis

This study demonstrates that while a ketogenic diet improves metabolic parameters and reduces snack-directed behavior in diet-induced obese mice by remodeling hypothalamic melanocortin signaling, obesity-associated neuroendocrine alterations persist despite these beneficial changes.

Mateusz Grabowski, Konstancja Grabowska, Marta Nowacka-Chmielewska, Andrzej Małecki, Halina Jędrzejowska-Szypułka, Jaros (…)2026-07-02
🧬 biology

Scalable quantification of dynamic subcellular spatial organization in single cells across tissues

The paper introduces CellPolariS, a novel image analysis framework that overcomes existing limitations in throughput and spatial resolution to accurately quantify the dynamic subcellular polarity of diverse cell types across tissues, revealing critical insights into polarity changes during hematopoietic differentiation and its rapid temporal dynamics in living cells.

Dirk Loeffler, Soumen Bera, Shalmali Pendse, Marcus Harrell, Jessica Nunes2026-07-02
🧬 biology

Identification of Rare Variants in Candidate Genes Associated with Chemotherapy-Induced Peripheral Neuropathy

This prospective study of breast cancer patients utilized whole-exome sequencing to identify four rare variants in candidate genes (CYP2C8, SLCO1B1, ABCB1, and EPHA8) associated with moderate-to-severe chemotherapy-induced peripheral neuropathy, highlighting the potential role of low-frequency genetic variants in ADME and neurological pathways as predictors of treatment toxicity.

William M. Durham, Joan Roehl, Larisa M. Haupt, Kim E. Alexander, Paul J. Dunn2026-07-02
🧬 biology

From breeder flocks to processing plants: Multilocus sequence typing, antimicrobial resistance, and virulence gene profiles of Salmonella in the broiler production chain in Fujian, China

This study characterizes Salmonella isolates across the broiler production chain in Fujian, China, revealing that the dominant ST11 clone of Salmonella Enteritidis is widely distributed with high virulence conservation in breeding stages, while processing plants exhibit significantly elevated antimicrobial resistance rates.

Yi Shi, Xi Niu, Lei Fu, Xiaoping Wu, Song Wang, Ping Liu, Yijian Wu2026-07-02