3881 papers
This study demonstrates that sustained light exposure alters the microscale oxygen environment and shifts *Endozoicomonas* abundance within the gastrovascular cavity of *Galaxea fascicularis*, while highlighting significant physiological heterogeneity among individual polyps and the overall stability of the broader microbial community.
Seq2DomML is a novel sequence-based machine learning framework that utilizes a bidirectional LSTM model trained on physicochemical and evolutionary features to accurately predict protein domain boundaries in bacterial proteins without requiring structural coordinates or homologous domain assignments, outperforming established annotation tools.
This study introduces a framework that decomposes blood pressure polygenic risk scores into tissue-specific components, revealing that context-dependent genetic effects and gene-environment interactions (such as ATP2B1's response to medication) significantly influence cardiovascular disease risk and improve prediction accuracy compared to traditional aggregate scores.
This study utilizes whole-genome sequencing to detect house dust mite-derived DNA in human lung tumors, revealing its presence in both cancerous and normal tissues with higher frequency in smokers, while identifying specific associations with immune cell composition and bacterial co-detection patterns in lung cancer among never-smokers.
This study demonstrates that MDMX mutations K478R and N448C differentially alter the structural dynamics and binding affinity of the MDM2–MDMX complex to inhibitors MMRi6 and MMRi64, suggesting that personalized inhibitor selection is necessary to effectively disrupt the complex and restore p53 activity in cancer therapy.
This study employs a multi-tiered computational framework to demonstrate that the allosteric activator PAM_16A enhances the calcium affinity of the TMEM16A chloride channel by binding near the calcium site and dehydrating the pocket, thereby activating the channel without significantly altering its gating efficacy.
By analyzing thousands of citizen science photographs and new observations, this study reveals that the Guira Cuckoo is a highly opportunistic generalist predator with a broader diet than previously recognized, including significant predation on diverse vertebrate taxa such as amphibians, reptiles, birds, mammals, and fish.
This study utilizes untargeted cross-matrix metabolomics of urine and feces to reveal that children with autism spectrum disorder exhibit a systematic metabolic disorder characterized by disrupted tryptophan metabolism, impaired mitochondrial function, and altered gut microbiota-metabolite interactions.
This study integrates multi-cohort genomic and transcriptomic data from Chinese prostate cancer patients to uncover ancestry-specific regulatory mechanisms, identifying UHRF1BP1 as a key oncogenic driver that promotes androgen receptor signaling and represents a novel therapeutic target for enzalutamide-resistant disease.
This pilot study of 60 Libyan coronary heart disease patients reveals a high prevalence of ε4-containing APOE genotypes and a significant link between smoking and genotype in males, while highlighting critical methodological limitations such as poor assay concordance and the lack of a control group that necessitate validation in larger, standardized future research.