1625 papers
This study characterizes the African clade-3 bat Sarbecovirus PRD0038, demonstrating its inability to infect human cells via ACE2, its susceptibility to existing antivirals and some antibodies, and its potential to utilize intermediate hosts, thereby defining the functional and immunological constraints that limit its emergence while highlighting available therapeutic countermeasures.
Using airborne lidar and field data across the United States and Puerto Rico, this study reveals that while forest structural diversity is a significant driver of taxonomic diversity for birds, mammals, and beetles, these relationships are taxon-specific and vary in strength and direction, unlike the weak association observed for plants.
This genome-wide analysis of six millet and related C₄ grass species reveals that synonymous codon usage bias actively shapes CpG dinucleotide architecture in coding sequences, suggesting that codon choice and arrangement preconfigure the structural substrate for gene body methylation and extend the functional role of codon bias beyond translational efficiency to include an epigenetic dimension.
This study reveals that type 2 diabetes and cardiovascular magnetic resonance-derived cardiac remodeling share significant genetic architecture, identifying 156 shared loci and prioritizing 18 candidate genes, including six core immune-regulated genes, that may drive diabetes-related cardiac structural alterations.
This study utilizes shotgun metagenomic profiling to demonstrate that dysbiotic shifts characterized by an increased ratio of *Streptococcus* and *Veillonella*-associated species (sCAG5 and sCAG4) to butyrate-producing bacteria (sCAG10) serve as a novel intestinal microbial indicator of hepatitis E disease severity.
This study identifies optimal methyl jasmonate induction conditions and utilizes RNA-seq combined with WGCNA to pinpoint key genes, including the significantly upregulated UGT88F3 and 15 other candidates, involved in the biosynthesis of the medicinal compound kinsenoside in both diploid and tetraploid *Anoectochilus roxburghii*.
This study demonstrates that low GROα/CXCL1 expression predicts poor survival and promotes tumor progression in triple-negative breast cancer, revealing a context-dependent tumor-suppressive role that warrants further investigation as a prognostic biomarker and therapeutic target.
This study presents the first comprehensive assembly and characterization of the *Camellia pitardii* mitochondrial genome, revealing its structural features, gene content, and evolutionary dynamics while highlighting topological incongruence between mitochondrial and chloroplast phylogenies to provide a foundational resource for future comparative genomics and germplasm utilization in the genus *Camellia*.
This study comprehensively identifies and characterizes 283 CYP450 genes in *Coptis chinensis*, revealing their uneven chromosomal distribution, tissue-specific expression, and significant upregulation under low-light and long-photoperiod conditions, which suggests a regulatory role in alkaloid accumulation mediated by light-responsive and MeJA elements.
By integrating public genetic and expression resources, this study demonstrates that Alzheimer's disease risk and β-amyloid burden represent distinct biological processes, identifying BIN1 as a broad risk anchor while showing that the previously implicated ZNF227 signal is primarily driven by APOE-region variants rather than independent amyloid pathology.