3881 papers
This study establishes a human iPSC-derived gastric antrum organoid platform capable of modeling loperamide-induced dysmotility-like alterations and evaluating the partial restorative effects of the prokinetic drug mosapride through morphological, molecular, and transcriptomic analyses.
This paper introduces COBS, a method for controlled overlapping community detection in breast cancer PPI networks that refines crisp partitions to assign functionally interpretable multi-memberships, alongside new centrality measures that leverage these overlapping contexts to improve protein prioritization and biological insight.
This study demonstrates the feasibility of a flexible, graphene-functionalized embroidered textile biosensor capable of non-invasively detecting Alzheimer's disease biomarkers in saliva, with reduced graphene oxide (rGO) electrodes functionalized with anti-tau antibodies showing the most stable and selective performance.
This study presents the first molecular characterization of Factor X deficiency in Nepal, identifying an ultra-rare homozygous F10 p.F71S mutation in two siblings that marks the first global report of this variant outside the Algerian Kabyle population, thereby challenging existing ethno-geographic paradigms of mutation distribution.
This study reveals that among *Pinus yunnanensis* seedlings of varying quality grades, Grade I seedlings exhibit the most stable seasonal allometric coordination of growth, photosynthetic pigments, and root strategies, whereas Grades II and III display progressively weaker coordination and stress resistance.
This study demonstrates that Sept7 orchestrates oligodendrocyte differentiation and myelination by coordinating cytoskeletal dynamics and scaffolding MAPK/ERK1/2 signaling, revealing a critical mechanism underlying age-related white matter degeneration.
This study demonstrates that in Xinjiang's saline-alkali deserts, perennial shrubs foster more diverse, stable, and complex rhizosphere bacterial communities than annual herbs by directly shaping microbial diversity and indirectly improving soil properties, thereby offering a strategic pathway for ecosystem restoration.
This in silico study identifies quercetin and luteolin from *Vernonia amygdalina* as promising dual-site inhibitors of the methicillin-resistant *Staphylococcus aureus* target PBP2a, with these phytochemicals demonstrating superior or comparable binding affinity to the allosteric site compared to the reference drug ceftaroline.
Chronic circadian desynchrony disrupts the stage-specific molecular and bioenergetic organization of spermiogenesis, particularly affecting elongated spermatids, which leads to mitochondrial dysfunction, impaired sperm function, and reduced male fertility.
This study identifies that the close spatial proximity of TLR2-expressing M2-like tumor-associated macrophages to glioma cells defines an unfavorable immune niche associated with poor prognosis and enhanced tumor invasion, suggesting TLR2 as a promising spatial biomarker and therapeutic target.