🧬 Category

q-bio

1816 papers

🧬 biology

Racialized Heteroscedasticity in Neuroimaging Features, Behavior Measures, and Neuroimaging-Based Predictive Models

This study of 4,736 ABCD cohort participants reveals that racialized heteroscedasticity, characterized by consistently higher variance in neuroimaging and behavioral data for Black participants, systematically induces disparities in prediction error and model reliability even when mean differences are absent, highlighting variance structure as a critical determinant of model generalizability across diverse populations.

Christopher Fields, Matthew Rosenblatt, Joseph Aina, Jannat Thind, Annie Harper, Chyrell Bellamy, Xin Zhou, Alexandra Po (…)2026-06-28
🧬 biology

Pleiotropic genetic links between high-grade serous ovarian cancer and female reproductive timing traits

This study utilizes large-scale genomic analyses to identify substantial genetic overlap and shared susceptibility loci between high-grade serous ovarian cancer and female reproductive timing traits, revealing convergent biological mechanisms in immune regulation and chromatin organization that extend the incessant ovulation hypothesis into a genetic framework.

Changqing Jiang, Jingjing Zhang, Linlin Zhang, Xiangyu Wang, Guoliang Li, Xiangyu Liu2026-06-28
🧬 biology

The Role of Gut Microbiome in Mental Health: A Systematic Review with Narrative Synthesis

This systematic review of 32 human studies indicates that while gut microbiome dysbiosis is consistently associated with depression and anxiety and that microbiome-targeted therapies show modest symptomatic benefits, causal conclusions remain tentative and future research requires more rigorous, standardized methodologies to establish definitive causal links.

Sheikh Sharmeen, Sanjoy Biswas, Khodeja Akter, Suhala Sheherin, Rehnuma Abdullah, Md Joni Mia, Borun Chandra2026-06-28
🧬 biology

Hepatitis B virus integrations promote EMT via upregulation of PAK3 expression in HepG2.2.15 cells

This study demonstrates that Hepatitis B virus integration, specifically at the chrX:111,009,033 site within the PAK3 gene, upregulates PAK3 expression to induce epithelial-mesenchymal transition and enhance metastatic potential in HepG2.2.15 cells, thereby promoting hepatocarcinogenesis through the activation of JAK/STAT and MAPK signaling pathways.

Chao Huang, Haisen Yin, Mengjuan Lin, Lei He, Kunqiao Hong, Xiufang Dai, Rui Zhou, Peng Ruan2026-06-28
🧬 biology

In Silico Development and Assessment of Hybrid Antimalarials as Falcipain Inhibitors

This study utilized in silico drug repurposing and rational hybrid design to identify and develop potent falcipain inhibitors for malaria treatment, demonstrating that combining high-affinity non-antimalarial compounds like Telithromycin with existing antimalarials yields superior hybrid candidates, particularly TELI-ATOVA, which warrants further experimental validation.

Siyanbola Oluwagbemiga Ibrahim, Darius Daniel Dogari, Kazeem Akano2026-06-28
🧬 biology

The Effect of Microgravity on the Human Voice, Phonation- A Single Case Study

This single-case study demonstrates that exposure to microgravity induces significant, subclinical alterations in human phonation—specifically marked reductions in vocal stability and contact quotient alongside increased jitter—likely caused by systemic fluid shifts and altered respiratory mechanics, thereby highlighting the need for continued monitoring and the potential use of vocal metrics as a health indicator for astronauts.

Adél Bihari, Ádám Schlégl, Tamás Perlaki, Petra Hermann, Zsolt Garami, Eszter Dabasi, Tamás Hacki2026-06-28
🧬 biology

A stabilized abdominal imaging platform for intravital interrogation of preclinical omental metastatic niche models

This paper presents a mechanically stabilized abdominal imaging platform that enables high-resolution, longitudinal intravital visualization of the omental metastatic niche in live mice by isolating the tissue from respiratory motion while preserving physiological dynamics, thereby overcoming the limitations of current methodologies for studying peritoneal cancer progression and immunotherapy responses.

Román García-Fuentes, Nicolás López de Aguileta, Beatrice Pinci, Daniel Moreno-Luqui, Yufei Zheng, Ainara Salgado-Pascua (…)2026-06-28
🧬 biology

Immuno-PET imaging of CD38 expression in multiple myeloma using a 64Cu-labeled nanobody

This study demonstrates that a 64Cu-labeled anti-CD38 nanobody (WF121) enables specific, high-contrast immuno-PET imaging of CD38 expression in multiple myeloma xenografts, validating its potential as a non-invasive companion diagnostic for guiding targeted therapies.

Sébastien GOUARD, Tacien Petithomme, Patricia Le Saëc, Vincent Nguyen, Judith Fresquet, Séverine Marionneau-Lambot, Clém (…)2026-06-28
🧬 biology

Comparative analysis of the severity of spatial memory deficits under hormonal environmental and pharmacological interactions in the Morris Water Maze

This study demonstrates that while chronic stress, aluminum chloride exposure, and tramadol administration all impair spatial memory in animal models, the combination of hormonal loss (ovariectomy) and environmental toxicity (aluminum chloride) induces the most profound hippocampal dysfunction, whereas stress accelerates memory loss but shows a complex kinetic response.

Jospin Chirac NOUBOUWO, Cécile Evodie TONPOUWO2026-06-28