4040 papers
This paper proposes a reproducible, topology-based method that reconstructs the physical spatial coordinates of biological networks by minimizing effective potential energy, thereby transforming topological data from sources like STRING into a metric space suitable for quantitative physical and mathematical analysis.
This study demonstrates that specific RAB5A variants associated with bipolar disorder disrupt endolysosomal trafficking and neuronal function in both fruit fly and mammalian models, validating Drosophila as an effective system for assessing the pathogenicity of psychiatric disorder-related genetic variants.
This study reveals that the OsEIN2-OsEIL1/2-OsNAP module negatively regulates rice thermotolerance and promotes leaf senescence by directly activating OsNAP expression and repressing the thermotolerance factor OsEIL5, thereby triggering ROS accumulation and cell death under heat stress.
The study introduces TrypOne, a sensitive, specific, and field-deployable one-pot CRISPR-LAMP assay that enables rapid, fluorescence-based detection of active *Trypanosoma brucei* infections with performance comparable to gold-standard PCR, offering a promising tool for One Health surveillance and treatment monitoring.
This study demonstrates that 3D tumor spheroid models effectively mimic in vivo necrotic environments to validate the colonization, antibiotic sensitivity, and therapeutic efficacy of anaerobic bacteria like *Clostridium sporogenes*, serving as a crucial intermediate step between in vitro and in vivo cancer research.
This study identifies the uORF-encoded micropeptide TCEA1-45aa as a hypoxia-responsive driver of hepatocellular carcinoma progression that stabilizes ENO1 to enhance glycolysis via an m⁶A–YTHDF3-mediated translational mechanism, revealing a potential therapeutic vulnerability in HCC.
Cyclin A2 overexpression drives replication stress and subsequent chromosome breakage and aneuploidy specifically in p53-deficient cells by forcing premature cell-cycle progression despite impaired DNA replication, thereby potentially accelerating tumor evolution through genome diversification.
This study presents the first genome-wide characterization of simple sequence repeats (SSRs) in coriander and four related Apiaceae species, revealing their distinct distribution patterns, low cross-genus primer transferability, and the utility of newly developed markers for assessing the crop's limited genetic diversity.
This study identifies stable Caveolin-1–EEA1 endosomes as a conserved, clathrin-independent platform in developing neurons that coordinates TGFβ receptor trafficking and signaling during axonal specification and elongation.
This study characterizes the bovine-derived probiotic *Lactiplantibacillus plantarum* HCD07 and demonstrates that while its preventive and therapeutic administration mitigated weight loss in ETEC O8-challenged mice, it did not establish clear mucosal protection or a microbiota-mediated mechanism, indicating a need for further evaluation of its functional endpoints.