1816 papers
This study demonstrates that the probiotic *Bacteroides intestinalis* AM-1 ameliorates acute liver failure by rewiring glutathione and bile acid metabolism to restore mitochondrial homeostasis and suppress necro-apoptosis, thereby significantly reducing liver injury and mortality.
This pedigree-anchored systematic review and meta-analysis demonstrates a robust, directionally consistent association between mitochondrial macro-haplogroup U and Multiple Sclerosis risk across Arab, Iranian, and European populations, yielding a pooled odds ratio of 1.91 despite the limited power of the initial Arab discovery cohort.
This study investigates the differential placental immune mediators in pregnant women with preeclampsia, with or without SARS-CoV-2 infection, revealing that specific alterations in immune molecule expression at the maternal-fetal interface may explain why preeclamptic women infected with COVID-19 exhibit a less severe clinical presentation compared to those with COVID-19 alone.
By integrating Mendelian randomization with multi-omics transcriptomic and proteomic data, this study identifies NPC2, PCDH12, and IL10RB as novel downregulated therapeutic targets for spina bifida and proposes tamibarotene as a potential drug candidate.
This study identifies TRIM36 as a critical positive regulator of septic inflammation that drives TLR4 signaling by catalyzing K63-linked ubiquitination of TAK1, thereby promoting NF-κB activation and cytokine production, which suggests its potential as a therapeutic target for sepsis.
This study demonstrates that microbiome signals in low-biomass lung cancer tumor, adjacent tissue, and blood samples are weak, inconsistent, and indistinguishable from contamination, highlighting the critical need for rigorous validation methods like technical replicates and absolute quantification to ensure data reliability.
This study demonstrates that hemiparkinsonian rats exhibit impaired multimodal sensorimotor gating and heightened sensitivity to 5-HT2 receptor-mediated hallucination-like behaviors, suggesting that upregulated 5-HT2 receptors contribute significantly to psychosis-associated symptoms in Parkinson's disease.
This study developed a machine learning-based prognostic model using 11 immunogenic cell death-related genes to effectively stratify neuroblastoma patients by risk, revealing distinct differences in immune microenvironment, signaling pathways, and drug sensitivity between high- and low-risk groups.
This study demonstrates that river freezing in a North Chinese mountain stream significantly alters environmental conditions and macroinvertebrate community structure by shifting diversity patterns from being jointly shaped by water chemistry and spatial distance to being dominated by specific abiotic filters and dispersal limitation, respectively.
While low water flow enhances pigmentation and lipid reserves in newly settled *Acropora digitifera* corals, it significantly increases early mortality risk compared to moderate and high flow regimes, demonstrating that optimal conditions for physiological development do not necessarily maximize survival.