1816 papers
This study validates [3H]5-MOP as a novel, highly selective, and high-affinity radioligand for the CSF1R receptor that outperforms existing tools like [3H]CPPC by lacking cross-reactivity with other brain kinases, thereby enabling accurate neuroimaging of neuroinflammation and drug occupancy.
This study reveals that mucosa-associated invariant T (MAIT) cells are enriched and highly functional within the follicular fluid of patients with polycystic ovary syndrome (PCOS), where they exhibit increased immunoreactivity and cytokine secretion that likely contribute to the ovarian inflammatory environment.
This in vitro split-sample study demonstrates that photobiomodulation significantly enhances the cellular distribution, fibrin architecture, and growth factor release of platelet-rich fibrin in a wavelength-dependent manner, with 940 nm optimizing structural integrity while 660 nm and 810 nm preferentially boosting specific growth factor responses.
This study systematically characterizes the 70-member WRKY gene family in Hass avocado, revealing its evolutionary expansion via segmental duplication and identifying specific candidate genes that play crucial roles in regulating differential defense responses against insect herbivory and pathogen infections.
This study demonstrates that *Streptococcus suis* exhibits strain-specific growth heterogeneity in host-mimicking conditions that is independent of clinical origin, highlighting the critical role of metabolic adaptation and nutrient availability in shaping bacterial fitness.
This study establishes generic allometric regressions for organ mass and blood flow across mammalian species, demonstrating their high predictive accuracy and revealing that scaling in hyperperfused organs depends on both body and organ mass to support cross-species pharmacokinetic extrapolation and the integration of biological traits.
The study identifies a class of oncogenic mutations termed BREADCROMs that disrupt lineage differentiation and promote tumorigenesis by inducing broad DNA methylation alterations that lock stem cells in a constrained, intermediate state resistant to both reprogramming and terminal differentiation.
This study validates the use of insertable cardiac monitors to establish the first long-term heart rate baseline for conscious, unrestrained jaguars, revealing that activity, time of day, and feeding schedules are primary drivers of their cardiac rhythms.
This study demonstrates that dysfunction of basal forebrain parvalbumin neurons drives Alzheimer's disease progression by disrupting cortical network oscillations and directly exacerbating hippocampal pathology, ultimately leading to cognitive impairment.
This study identifies the glycosyltransferase B3GNT3 as a novel prognostic biomarker in lung adenocarcinoma that links Porphyromonas-associated microbial dysbiosis to mTORC1 pathway hyperactivation and adverse patient outcomes through integrative multi-omics analysis and experimental validation.