🧬 Category

q-bio

1816 papers

🧬 biology

Spatial and single-nucleus transcriptomics reveal the complexity of genomic imprinting in maize

By integrating spatial transcriptomics and single-nucleus RNA sequencing, this study reveals that genomic imprinting in maize endosperm is highly cell-type specific, with the majority of imprinted genes restricted to single cell types and a predominance of paternally expressed genes, suggesting that post-fertilization differentiation shapes the spatial and cellular complexity of this epigenetic phenomenon.

Tao Li, Yi Jiang, Mingyue Zhang, Kesen Zhu, Siqi Jiang, Xuerong Yang, Hongjun Liu, Jiechen Wang, Xiaomei Dong, Junpeng S (…)2026-06-26
🧬 biology

Kolaviron Exerts Protection Against Atrazine-evoked Hepatorenal Injury by Targeting Apoptosis, Oxidative Stress, Inflammation Mediated Nf-kb/Cox-2/Il-1β and Beclin-1/Lc3-ii Signaling Cascades in Rats

This study demonstrates that kolaviron, a natural biflavonoid from *Garcinia kola*, effectively protects against atrazine-induced hepatorenal injury in rats by mitigating oxidative stress, inflammation, apoptosis, and autophagy through the modulation of NF-κB/Cox-2/IL-1β and Beclin-1/LC3-II signaling pathways.

Adedayo A. Adebisi, Hadassah S. Amana, Cynthia N. Ikeji, Ebenezer O. Farombi2026-06-26
🧬 biology

COVID-19 Vaccine Reactogenicity Marks an Innate Inflammatory Response Associated With HLA Variation and Enhanced Protection

This study demonstrates that vaccine reactogenicity is driven by an interaction between specific HLA genotypes (notably HLA-A*03:01) and innate inflammatory responses, serving as a clinically observable correlate of enhanced protection against SARS-CoV-2 infection.

Jill Hollenbach, Anshika Srivastava, Demetra Chatzileontiadou, Anurag Adhikari, Rayo Suseno, Sean Lin, Juliano Boquett (…)2026-06-26
🧬 biology

Harvestmen assemblages (Arachnida: Opiliones) reveal compositional shifts associated with riparian wetland degradation in a tropical dry forest-oil palm landscape

This study demonstrates that replacing riparian tropical dry forest with oil palm monoculture in northern Colombia significantly reduces harvestmen abundance, richness, and diversity while driving compositional homogenization, thereby identifying these arachnids as sensitive indicators of riparian microhabitat degradation.

Daniela Ahumada-C., Angie Estevez-Vargas, Reynaldo Fajardo-Herrera, Harold Castillo-Navarro2026-06-26
🧬 biology

Combined Effects of 8 Weeks of Endurance Training and MitoQ Antioxidant Supplementation on PGC-1α and PDK4 Gene Expression in Skeletal Muscle of Young and Aged Male Wistar Rats

This study demonstrates that an 8-week combination of endurance training and MitoQ supplementation induces synergistic increases in PGC-1α and PDK4 gene expression in young rats and partially restores these responses in aged rats, though the magnitude and nature of the interaction vary significantly by age and specific gene target.

Hanie Salari, Mohsen Aminaei, Soheil Aminizadeh2026-06-26
🧬 biology

Granzyme A-expressing Terminal Effector T Cells Dedifferentiate into Long-lived Memory T Cells

This study challenges the strict bifurcation model by demonstrating that while early memory T cells primarily arise from Granzyme A-negative precursors, Granzyme A-expressing terminal effector T cells can subsequently dedifferentiate into long-lived functional memory cells, resulting in a mixed memory population derived from both linear and bifurcated differentiation paths.

Nu Zhang, Chaoyu Ma, Wei Liao, Saranya Srinivasan, Chenhui he, Kenneth Fan, Tyng-An Zhou, Courtney Segura-Cepero, Heetan (…)2026-06-26
🧬 biology

Ribozyme-optimized CVS-N2cΔG Rabies Virus with Hyper-diverse Barcodes for High-fidelity Single‑Neuron Projection Connectivity

This study reports a ribozyme-optimized CVS-N2cΔG rabies virus platform that utilizes Twister-based configurations to dramatically enhance barcode diversity and rescue efficiency, thereby enabling high-fidelity, collision-free mapping of single-neuron projection connectivity in the mouse visual pathway.

Lei Jin, He Zhang, Daoyin Liu, Xueping Gao, Xiangyu Ge, Yahui Li, Xia Zhang2026-06-26
🧬 biology

Reduced lactylation-regulator expression coupled with glycolytic activation marks an immunometabolic state associated with clinical stratification in sepsis

This study reveals that sepsis is characterized by a reproducible immunometabolic state where activated glycolysis and lactate programs coincide with reduced expression of canonical lactylation regulators, a signature that correlates with monocyte dysfunction, clinical stratification, and early mortality risk.

Geying Xi, Qian Wu, Biao Zhang2026-06-26
🧬 biology

Core Activation Patterns Across Different Figure Skating Jumps

This study utilizes synchronized sensor data to demonstrate that core muscle activation in figure skating jumps shifts from right-side to left-side dominance during flight and requires significantly higher oblique tension for triple jumps compared to doubles, driven by rotational velocity rather than airtime, thereby offering a quantitative framework for optimizing jump technique and strength training.

Pavla Nikelova, Vilem Hlavsa, Michal Magiera, Jaroslav Uchytil, Martina Ladrova, Sarka Cenkova, Radek Martinek, Roman Va (…)2026-06-26