1816 papers
This paper presents a computational model demonstrating that altered gravity increases neuronal firing and burst rates by incorporating gravity-sensitive mechano-gated ion channels and firing rate adaptation into excitatory networks, thereby bridging the gap between historical observations and neuronal activity mechanisms.
This study demonstrates that self-supervised foundation models trained on unlabeled sleep EEG data capture fine-grained within-stage microstructure that provides incremental health screening value beyond traditional coarse staging and standard signal summaries.
This study demonstrates that hinokinin can be efficiently encapsulated into PLGA and PLGA-PEG nanoparticles with high stability and rapid release, though the resulting nanosystems showed comparable or reduced antiproliferative activity against cancer cells in vitro compared to the free drug.
This paper presents a low-dose, lensless deep-ultraviolet holographic microscopy platform utilizing standard visible-light CMOS sensors to achieve centimeter-scale, label-free biochemical imaging with high-throughput, chemically specific contrast and sub-micron resolution.
PREDetector v4.0 is an updated, interactive web platform that enables comprehensive genome-wide prediction and functional analysis of bacterial regulons by integrating over 9,000 genomes and 2,000 curated motifs with dynamic threshold adjustment, reliability assessment, and direct links to external annotation resources.
This study demonstrates that long-term exposure to natural climates (tropical, temperate, and cold) induces adaptive differences in cutaneous thermal sensations among indigenous populations, with tropical indigenes exhibiting significantly higher thermal thresholds and lower sensitivity compared to those from colder regions, even when living in modernized environments.
This study reveals that spatial fluid shear stress gradients induce immediate and sustained biomechanical alterations in microvascular endothelial cells, including reduced migration speed, enhanced collective directional movement against the flow, and increased traction forces, which are mechanistically governed by FAK-mediated mechanotransduction and TGF-β1 signaling, respectively.
This paper proposes a unified dynamical framework that models both development and aging as stochastic trajectories on a deformable energy landscape, where development represents relaxation into stable attractor states while aging results from the progressive erosion of landscape stability leading to increased noise and tissue dysfunction.
This white paper presents consensus recommendations from a multidisciplinary workshop proposing a three-tiered "defence-in-depth" governance framework to balance the transformative potential of generative AI in biological sequence design with the urgent need to mitigate risks related to data bias, model opacity, and dual-use threats.
This study identifies specific deleterious plastid gene mutations responsible for albinism in chimeric *Cornus* cultivars, resolves their maternal phylogenetic lineages, and develops molecular markers to distinguish these morphologically similar varieties for precision breeding.