1816 papers
This study reveals that the C-terminal pro-invasive domain of CdGAP drives breast cancer metastasis by interacting with LIMD1 to activate WNT signaling, identifying this GAP-independent mechanism as a critical therapeutic target for triple-negative breast cancer.
The paper introduces RmvLMM, a scalable and powerful statistical framework that utilizes orthogonal rotation and a parallelized divided-and-combined strategy to overcome computational bottlenecks in large-scale multi-trait genome-wide association studies, demonstrating superior efficiency and power over existing tools like GEMMA while successfully identifying significant genetic variants and drug targets in UK Biobank data.
This study presents a high-quality, haplotype-resolved genome assembly of the landrace radish 'Huangzhou', revealing that its high dry matter content is driven by increased cellulose accumulation and upregulated cellulose synthase genes, while also identifying genetic adaptations to local environmental conditions.
This study demonstrates that programmable CRISPR-Cas9 and CRISPR-dCas9 systems can be engineered to specifically target resistance and virulence genes in multidrug-resistant Staphylococcus aureus, achieving either bactericidal elimination of mecA or selective suppression of virulence factors like agrA and spa without compromising bacterial viability.
This study demonstrates that β-hydroxybutyrate can independently sustain essential metabolic and functional properties of brain tissue, including the ability to recover from severe energetic challenges, in the complete absence of exogenous glucose.
This study demonstrates that polypropylene microplastics alter copper partitioning in *Nymphaea* 'Black Beauty' by shifting copper accumulation from roots to leaves, thereby intensifying chlorophyll loss and triggering distinct organ-specific metabolic and transcriptomic stress responses.
This study demonstrates that habitual physical activity selectively preserves core mitochondrial bioenergetic programs and energetic function in human skeletal muscle and other tissues by counteracting the specific, coordinated proteomic remodeling associated with aging.
This paper presents a computationally efficient reduced model of AMPA receptors that captures TARP-dependent kinetic differences, revealing how variable TARP expression enables neuronal firing during low-frequency stimulation and offering a valuable tool for investigating epilepsy-related network excitability.
This study systematically identifies ten ARR-B genes in watermelon, characterizing their genomic features, subcellular localization, and expression patterns to reveal their critical roles in plant development and specific responses to drought, salt, and cold stresses.
This study compares three eye-tracking-enabled VR headsets for behavioral research and finds that the Meta Quest Pro offers superior practical suitability due to its higher data yield, better usability, and lower cybersickness, despite the HP Reverb G2 Omnicept demonstrating lower angular error in successful sessions.