1816 papers
This study reports the first identification of a bisexual population of the previously considered parthenogenetic tick *Amblyomma rotundatum* in the Amazon biome of Brazil, demonstrating the presence of males and females in comparable proportions both in the field and under laboratory conditions.
This study identifies UCHL1 as an oncogenic deubiquitinase that drives lung cancer progression by stabilizing the YAP1 protein and reprogramming ceramide metabolism, thereby establishing the UCHL1–YAP1–ceramide axis as a promising therapeutic target.
This study reveals that global Gabrd deficiency triggers a developmentally restricted, compensatory mechanism involving Pleiotrophin-mediated myelination of parvalbumin-positive inhibitory axons, which fortifies seizure resistance and suggests myelination enhancement as a novel therapeutic strategy for refractory epilepsy.
This study utilizes molecular dynamics simulations to elucidate the structural determinants of the essential PEX5–PEX14 interaction in trypanosomes and identifies SuFEx-derived naphthoquinones as promising small-molecule inhibitors that effectively mimic the native recognition motif to disrupt glycosomal protein import.
This systematic qualitative synthesis reveals that physical activity, alongside other lifestyle factors like diet, BMI, and smoking, significantly modulates the gut microbiome by increasing beneficial commensal bacteria and anti-inflammatory modulators.
This paper introduces Nonlinear Fourier Re-weighting (NFR), a rapid, prior-free algorithm that enhances microscopy resolution by non-iteratively re-balancing Fourier spectrum components, effectively overcoming optical diffraction limits and aberrations without requiring a point spread function.
This study demonstrates that transcriptional heterogeneity, rather than mean gene expression, predicts clonal selection in ageing haematopoiesis by revealing that increased variability in stem cell gene expression programs drives the expansion of specific clones and is conserved across species as a marker for myeloid malignancy risk.
This study demonstrates that compensatory lung growth following pneumonectomy is a regionally specific process driven by Fgfr2b signaling, which is essential for maintaining epithelial integrity and preventing fibrotic remodeling, with an embryonic Fgfr2b-responsive signature that is diminished in human lung diseases.
This paper proposes that the Gini coefficient serves as a useful non-parametric metric to assess the regulability and origin of metabolites, demonstrating that tightly regulated endogenous compounds exhibit low coefficients while exogenous substances show higher values, with ergothioneine displaying intermediate variability indicative of its dietary origin.
This study introduces two geometric measures of EEG spectral dynamics, trajectory curvature and effective rank, which reliably distinguish conscious from unconscious states across both propofol anesthesia and natural sleep, offering a mechanism-sensitive tool for tracking the loss of consciousness.