4319 papers
This study demonstrates that while female CD1 mice exhibit greater peripheral metabolic protection against diet-induced obesity compared to males, both sexes experience similar central hypothalamic oxidative stress, highlighting the model's value in capturing human genetic diversity and sex-specific metabolic responses.
This study analyzes 40 high-quality *Pseudomonas fluorescens* genomes to reveal an exceptionally open pan-genome structure where strain-specific accessory genes drive diverse plant growth-promoting traits and biosynthetic capabilities, highlighting the species' genomic plasticity as a key factor in its ecological adaptability and potential for sustainable agriculture.
This study demonstrates that optimizing the balance between glucose and casamino acids in a semi-defined medium, while avoiding soybean oil, significantly enhances azomycin production by *Streptomyces eurocidicus*, achieving a final titer of 69.18 mg/L in a 3L bioreactor.
This study analyzes DNA methylation patterns in 62 pancreatic ductal adenocarcinoma patient-derived organoids to identify four distinct methylation-based clusters that reveal tumor heterogeneity and biological processes beyond existing transcriptomic subtypes, potentially guiding future treatment strategies.
This study elucidates the molecular mechanism of programmed B chromosome elimination in *Aegilops speltoides* roots, revealing that the overexpression of B-encoded cohesin (SYN2-B) and centromeric histone (CENH3-B) genes, potentially regulated by ethylene signaling, disrupts normal chromosome segregation to drive selective chromosome loss.
This study integrates cis-eQTL Mendelian randomization and colocalization analyses to prioritize *MAPK3* as a protective candidate and *UQCC1* as a risk-increasing candidate for osteoarthritis, while highlighting the need for further experimental validation to confirm causal mechanisms and distinguish signals from the adjacent *GDF5* locus.
This study characterizes the Cooum River in Chennai as a significant environmental reservoir for multidrug-resistant and hypervirulent *Klebsiella pneumoniae*, highlighting the critical public health risks posed by the high prevalence of colistin-resistant strains carrying key virulence genes in urban aquatic ecosystems.
By integrating single-cell and spatial transcriptomics with computational modeling, this study defines a C3-centered multicellular ecology in colorectal liver metastasis characterized by a specific malignant state and stromal-vascular interactions that drive poor prognosis and reveal a MAPK-linked network vulnerability potentially targetable by PD-0325901.
This study demonstrates that the malignant differentiation state of B-cell lymphomas, rather than histological subtype, causally dictates the spatial organization and immune composition of the tumor microenvironment, revealing a shared developmental continuum where dark zone states drive immune depletion and post-germinal center states promote immunosuppression.
This study identifies DIP2C as an independent favorable prognostic biomarker and tumor suppressor in kidney renal clear cell carcinoma (KIRC) through comprehensive pan-cancer bioinformatic analyses and in vitro functional validation demonstrating that its downregulation correlates with poor survival and enhanced cell migration.