4364 papers
This study demonstrates that single-cell foundation models can predict durable CAR T-cell persistence in pediatric B-ALL patients from pre-infusion scRNA-seq data with high accuracy, achieving clinically actionable insights even without perfect cell annotation and identifying CD8+XCL1/2+ cells as a key biomarker for long-term response.
This study demonstrates that encoding intermittent parathyroid hormone signals into preconditioned stem cell-derived exosomes and delivering them via a thermosensitive hydrogel effectively repairs osteoporotic bone defects by simultaneously promoting osteogenesis and angiogenesis, restraining osteoclastogenesis, and modulating the inflammatory microenvironment through the activation of the PA-PLD-LATS1/YAP signaling axis.
This study demonstrates that periodontal ligament stem cells suppress macrophage-driven inflammation and promote oral tissue healing by reprogramming pyrimidine metabolism to inhibit NLRP3 inflammasome activation, a mechanism validated by the therapeutic efficacy of the pyrimidine precursor triacetyluridine.
By analyzing over 9,000 mitogenomes, this study reveals that fine-scale maternal genetic structure and recent population expansions in the Circum-Baltic region were significantly shaped by Bronze and Iron Age demographic processes, uncovering distinct trajectories such as Sweden's post-Bronze Age recovery and a previously overlooked maternal genetic link between Estonia and Finland.
J-AST is a free, open-source, web-based platform that automates and unifies the analysis of disk diffusion assays and Etests for antimicrobial susceptibility testing, offering high accuracy in resistance quantification and metadata management to support both research and clinical workflows.
This study reveals that in *Hydra*, the discharge of feeding-related desmoneme cnidocytes is finely regulated by a hierarchical and concerted crosstalk between stimulatory serotonin and allatotropin, which activate Gq-coupled GPCRs to increase cytosolic calcium, and inhibitory allatostatin-C, which antagonizes their effects.
This study establishes human choroid plexus brain organoids as a viable in vitro model for syringomyelia research, demonstrating their ability to produce physiologically relevant CSF-like fluid and revealing specific molecular pathways involving betaine, water, and ion transporters that respond to osmotic stress, thereby identifying potential non-surgical therapeutic targets for syrinx management.
Using a large sample from the ABCD Study, this research reveals that while excessive video gaming (≥3 hours/day) is linked to attention problems and ADHD, moderate gaming (<1 hour/day) is associated with enhanced cognitive performance and lower aggressive behavior compared to non-gamers.
This study identifies mesothelial cell plasticity as the critical determinant between lung regeneration and degeneration, revealing that a TWIST1-CCL2 axis drives pro-regenerative monocyte recruitment in pneumonectomy while its absence leads to fibrotic remodeling in chronic lung allograft dysfunction.
This study demonstrates that perinatal alcohol exposure induces sex- and age-dependent disruptions in emotional learning and reward processing in mice, characterized by adolescent fear deficits in both sexes and persistent male-specific increases in alcohol preference and altered circadian activity, underpinned by region-specific molecular changes in neurotransmitter and stress-related pathways.