4387 papers
This study utilizes TMT-based proteomics, OCT, and ERG to identify early retinal pathological changes and differentially expressed proteins in an AlCl3/D-gal-induced sporadic Alzheimer's disease mouse model, revealing significant retinal thinning and functional deficits alongside memory impairment.
This study reveals that while purifying selection is the dominant force maintaining mitochondrial function in Ethiopian *Lophuromys* rats, high-altitude adaptation involves rare, lineage-specific positive selection on protein-coding genes and likely relies on a combination of localized mitochondrial changes and alternative physiological mechanisms rather than widespread adaptive introgression.
This study demonstrates that EEG microstate analysis applied during naturalistic movie-watching can effectively capture empathy-related brain dynamics, revealing distinct condition-dependent patterns that correlate with event-related potentials, prosocial behavior, and trait empathy, thereby extending the method's utility beyond resting-state and clinical research.
This paper introduces STAR, a few-shot molecular property prediction framework that leverages assay descriptions as language priors to guide task selection and feature modulation, significantly improving performance on label-scarce datasets by complementing structural data with biological context.
This study systematically evaluates the genetic associations of 123 RNA modification enzymes with psychiatric disorders, identifying *NSUN2* and several other candidates as significant risk genes for bipolar I disorder and schizophrenia, with findings suggesting a consistent pattern of downregulation in patient brains.
This cross-sectional study of 302 pre-medical students in Punjab, Pakistan, reveals that high levels of academic stress associated with MDCAT preparation are significantly correlated with increased perceived cognitive difficulties and poor sleep quality, supporting the hypothesis that chronic academic pressure adversely affects neurobiological and cognitive functioning even before medical school entry.
This study addresses the critical issue of noise-induced fatigue in high-speed train drivers by developing a dual-modal PPG-EEG detection system that reveals a "central inhibition–peripheral compensation" mechanism and introduces a novel Dual-modal Integrated Fatigue Index (DIFI) with a three-level intervention strategy, achieving a 10.6% performance improvement over single-modal methods.
This study demonstrates that in Acute-on-Chronic Liver Failure (ACLF), reproducible disease-associated biology is more robustly captured by coordinated alterations in lipid classes and modules than by individual lipid species, revealing specific lipid programs linked to organ failure severity and shared critical illness mechanisms.
This study presents a high-quality chromosome-level genome assembly of the Tibetan brown bear, revealing its demographic history of population expansion and bottlenecks, as well as a unique carbohydrate-dominated metabolic adaptation for hibernation that distinguishes it from North American brown bears.
This study demonstrates that Wolbachia-mediated dengue control in *Aedes aegypti* remains robust and effective despite sublethal insecticide exposure, as the symbiont's density, pathogen blocking, and reproductive traits rapidly recover without compromising viral suppression.