4398 papers
This study demonstrates that a *Lacticaseibacillus paracasei* postbiotic, specifically via the cofactor 10-formyl-tetrahydrofolate, rescues glucose-impaired serotonergic signaling and improves physiological outcomes in *C. elegans*, an effect that is specifically antagonized by unmetabolized folic acid under glucose stress.
This multi-omic study identifies vasorin (VASN) as a novel, reproducible biomarker of cardiometabolic health in children with obesity, demonstrating consistent associations across genomic, epigenomic, transcriptomic, and proteomic layers that support its potential for early risk stratification in precision prevention strategies.
The probiotic mixture Golden Bifid (BSL) alleviates high-fat diet-induced obesity and dyslipidemia in mice by reshaping the gut microbiota and modulating lipid metabolism through the suppression of the FABP2-PPAR axis and regulation of key genes like HMG-CoA reductase and LXR-α.
This study demonstrates that in breast cancer, aldehyde stress driven by cancer stem cells and CD8⁺ T cell exhaustion are compartmentally decoupled, with tumor exclusion mediated by spatial segregation and protein checkpoint signaling rather than diffusible metabolites, suggesting that effective treatment requires a dual strategy targeting both CSC metabolism and T-cell restoration.
This exploratory genome-wide association study in an admixed Brazilian cohort identifies a significant genetic variant at the PASD1 locus (rs56035326) associated with reduced COVID-19 severity, marking the first evidence linking this gene to disease outcomes in such populations.
This study investigates the combined genotoxic and transcriptional effects of chronic low-dose-rate gamma irradiation and inorganic arsenite in CBA and C57BL/6 mice, revealing that while irradiation is the dominant stressor, concurrent arsenite exposure primarily induces oxidative DNA damage with non-additive or counteracting effects on gene expression and minimal strain-specific interactions.
This study utilizes TMT-based proteomics, OCT, and ERG to identify early retinal pathological changes and differentially expressed proteins in an AlCl3/D-gal-induced sporadic Alzheimer's disease mouse model, revealing significant retinal thinning and functional deficits alongside memory impairment.
This study reveals that while purifying selection is the dominant force maintaining mitochondrial function in Ethiopian *Lophuromys* rats, high-altitude adaptation involves rare, lineage-specific positive selection on protein-coding genes and likely relies on a combination of localized mitochondrial changes and alternative physiological mechanisms rather than widespread adaptive introgression.
This study demonstrates that EEG microstate analysis applied during naturalistic movie-watching can effectively capture empathy-related brain dynamics, revealing distinct condition-dependent patterns that correlate with event-related potentials, prosocial behavior, and trait empathy, thereby extending the method's utility beyond resting-state and clinical research.
This paper introduces STAR, a few-shot molecular property prediction framework that leverages assay descriptions as language priors to guide task selection and feature modulation, significantly improving performance on label-scarce datasets by complementing structural data with biological context.