🧬 Category

q-bio

4401 papers

🧬 biology

Molecular Characterization of erg2 and erg11 Genes in Azole- Resistant Candida Species Isolated from Patients with Vulvovaginal Candidiasis in Ibadan, Nigeria

This study characterizes azole-resistant *Candida* species isolated from women with vulvovaginal candidiasis in Ibadan, Nigeria, revealing a high prevalence of fluconazole resistance and identifying specific mutations in the *erg2* and *erg11* genes that underscore the urgent need for molecular surveillance to guide local treatment guidelines.

Abidemi Nurat Akinbami, Philip Adegboyega Idowu, Saheed Ayodeji Adekola2026-07-31
🧬 biology

Single-cell foundation models predict durable CAR T response despite imperfect cell annotation

This study demonstrates that single-cell foundation models can predict durable CAR T-cell persistence in pediatric B-ALL patients from pre-infusion scRNA-seq data with high accuracy, achieving clinically actionable insights even without perfect cell annotation and identifying CD8+XCL1/2+ cells as a key biomarker for long-term response.

Rong Fan, Leo Shen, Zhiliang Bai, Mingyu Yang, Na Li2026-07-31
🧬 biology

Encoding Intermittent Parathyroid Hormone Signals in Stem Cell Exosomes Enables Targeted Repair of Osteoporotic Bone Defects

This study demonstrates that encoding intermittent parathyroid hormone signals into preconditioned stem cell-derived exosomes and delivering them via a thermosensitive hydrogel effectively repairs osteoporotic bone defects by simultaneously promoting osteogenesis and angiogenesis, restraining osteoclastogenesis, and modulating the inflammatory microenvironment through the activation of the PA-PLD-LATS1/YAP signaling axis.

Jiaqi Fang, Yiqing Wu, Xuejin Jin, Xinhui Wu, Bo Xu, Junkuan Shan, Liping Nan, Shuhao Liu, Wei Nie, Junjian Liu, Jinghua (…)2026-07-31
🧬 biology

Periodontal ligament stem cells control inflammation by pyrimidine metabolism

This study demonstrates that periodontal ligament stem cells suppress macrophage-driven inflammation and promote oral tissue healing by reprogramming pyrimidine metabolism to inhibit NLRP3 inflammasome activation, a mechanism validated by the therapeutic efficacy of the pyrimidine precursor triacetyluridine.

Jin Wook Hwang, Young Hun Son, Won Jong Park, Seung Hong Tak, Kwang Youl Lee, Min-Jung Park, Dong-Il Kim, Youn Ho Han2026-07-31
🧬 biology

Maternal contacts across the Baltic Sea – thousands of mitogenomes reveal maternal genetic structure and recent expansions in the Circum- Baltic region

By analyzing over 9,000 mitogenomes, this study reveals that fine-scale maternal genetic structure and recent population expansions in the Circum-Baltic region were significantly shaped by Bronze and Iron Age demographic processes, uncovering distinct trajectories such as Sweden's post-Bronze Age recovery and a previously overlooked maternal genetic link between Estonia and Finland.

Hovhannes Sahakyan, Maere Reidla, Ene Metspalu, Ivan A. Kuznetsov, Rodrigo Flores, Kadri Irdt Rezzakioğlu, Olga Utevska (…)2026-07-31
🧬 biology

Regulatory systems in Hydra: Serotonin, Allatotropin and Allatostatin-C crosstalk on Cnidocytes Activity

This study reveals that in *Hydra*, the discharge of feeding-related desmoneme cnidocytes is finely regulated by a hierarchical and concerted crosstalk between stimulatory serotonin and allatotropin, which activate Gq-coupled GPCRs to increase cytosolic calcium, and inhibitory allatostatin-C, which antagonizes their effects.

María Victoria Gavazzi, Jorge Rafael Ronderos, María Eugenia Alzugaray2026-07-31
🧬 biology

Utilization of Human Choroid Plexus Brain Organoids to Study Fluid Osmoregulation with Response to Osmotic Imbalance

This study establishes human choroid plexus brain organoids as a viable in vitro model for syringomyelia research, demonstrating their ability to produce physiologically relevant CSF-like fluid and revealing specific molecular pathways involving betaine, water, and ion transporters that respond to osmotic stress, thereby identifying potential non-surgical therapeutic targets for syrinx management.

Katherine J. Bradshaw, Dipak Pukale, Gowsia Banu Shaik, Peng Jiang, Nic D Leipzig2026-07-31
🧬 biology

Moderate vs. Excessive Video Gaming: Distinct Neurocognitive and Neural Activation Profiles in Preadolescence

Using a large sample from the ABCD Study, this research reveals that while excessive video gaming (≥3 hours/day) is linked to attention problems and ADHD, moderate gaming (<1 hour/day) is associated with enhanced cognitive performance and lower aggressive behavior compared to non-gamers.

Bader Chaarani, Leigh-Anne Cioffredi, Matthew Albaugh, Nicholas Allgaier, Robert Althoff, Alexandra Potter, Hugh Garavan2026-07-31
🧬 biology

Mesothelial Plasticity Specifies Divergent Pleural Immune Circuits that Instruct Lung Regeneration versus Degeneration

This study identifies mesothelial cell plasticity as the critical determinant between lung regeneration and degeneration, revealing that a TWIST1-CCL2 axis drives pro-regenerative monocyte recruitment in pneumonectomy while its absence leads to fibrotic remodeling in chronic lung allograft dysfunction.

Xin Sun, Le Xu, Kevin Chen, Barsha Dash, Bingpeng Yao, Rongbo Li, Xingan Wang, Zihe Zhou, Vincent Yu, Rebecca Salamon, P (…)2026-07-31