4605 papers
This study presents BioGPT-ClinVar, a parameter-efficient fine-tuning framework using Low-Rank Adaptation (LoRA) to adapt the 150-million-parameter BioGPT model for genomic variant interpretation, demonstrating effective convergence on a curated ClinVar dataset while providing an open-source, reproducible pipeline for future clinical and surveillance applications.
This paper demonstrates that while trained quantum Kolmogorov–Arnold networks are often classically simulable via low-bond-dimension tensor networks, genuine quantum advantage can be preserved and made trainable by employing discrete-logarithm encodings that embed number-theoretic hardness without succumbing to barren plateaus.
This study employs an integrated computational workflow combining machine learning, virtual screening, and molecular dynamics to identify Febuxostat as a novel, stable S1PR1 modulator with therapeutic potential for multiple sclerosis.
This study reveals that the Drosophila lipid scramblase Xkr promotes apoptotic cell clearance by interacting with dORP9 at ER-plasma membrane contact sites to facilitate non-vesicular phosphatidylserine transport to the cell surface, thereby serving as an alternative caspase-independent pathway for "eat me" signal exposure.
This study demonstrates that simulated hypogravity reduces cardiovascular demand during walking while virtual reality modulates physiological responses by delaying heart rate increases, confirming the safety and efficacy of combining AlterG treadmills with VR for preparing crews for future lunar and Martian missions.
Contrary to expectations, this study reveals that intense intrasexual competition partially mitigates the negative impact of heatwaves on male reproductive output in *Drosophila prolongata*, likely through a compensatory increase in reproductive investment, highlighting the critical role of interactive environmental stressors in shaping wildlife responses to climate change.
This study utilizes phylodynamic analysis of 336 measles virus strains to reveal that African transmission is driven by human mobility and frequent Asian introductions, characterized by prolonged cryptic circulation that underscores the urgent need for enhanced surveillance and vaccination to prevent global spread.
This study demonstrates that the CRISPR/Cas7-11 system serves as a precise, efficient, and low-toxicity RNA knockdown tool capable of inducing specific phenotypic changes in zebrafish embryos and driving differentiation in human embryonic stem cells with minimal off-target effects.
A neutral cannabinoid-rich *Cannabis sativa* L. extract mitigates UVB-induced oxidative stress and partially restores MITF transcriptional suppression in B16-F10 melanoma cells without significantly altering total melanin content, suggesting its potential as a photoprotective agent in dermatological formulations.
This study demonstrates that an edible vaccine developed by expressing conserved PspA B-cell epitopes fused to alpha-zein in transgenic tomato plants successfully protects mice against lethal pneumococcal challenge, highlighting a promising, affordable oral vaccination strategy.