4605 papers
This paper proposes a robust Transformer-based framework for drug–target interaction prediction that integrates bidirectional cross-attention, hybrid local–global semantic aggregation, and stabilized optimization to significantly outperform existing models like MolTrans, particularly in scarce-data and imbalanced scenarios.
This longitudinal study of 471 elderly participants in Qingdao provides the first evidence that a polygenic risk score based on calcium signaling pathway genes is significantly associated with both baseline hearing levels and the accelerated rate of age-related hearing deterioration, particularly in individuals aged 70 and older.
This study expands the genetic landscape of pheochromocytomas, paragangliomas, and pituitary adenomas by identifying pathogenic germline variants in known neuroendocrine genes and describing, for the first time, potential associations with DNA repair and telomere maintenance genes such as TERT and ATM.
This study demonstrates that long-lived mammals have evolved specific codon usage biases—such as depleting hypermutable stopogenic codons and favoring non-optimal codons to slow translation and improve protein folding—to minimize somatic mutations and proteostasis loss, thereby extending lifespan.
This study reveals that a Pinna nobilis Picornavirus (PnPV) infection caused 100% mortality and local extinction of larger fan mussels in the Venice Lagoon's Ottagono Alberoni area by October 2024, while smaller individuals in Coffa Val Grande showed greater tolerance, with mortality rates positively correlating with animal size, viral load, and immune cell depletion.
This study presents the first report of *Colletotrichum viniferum* as an emerging ripe rot pathogen in Indian grapevines, characterizing its phenotypic traits, pathogenicity, and genomic features—including virulence factors and cell wall-degrading enzymes—to establish a quantitative framework for disease management.
This study identified and validated a five-gene cysteine-related prognostic signature (SERPINE1, MATN3, BAALC, SLC7A3, and RNASE1) for gastric cancer, constructing a robust risk model and nomogram that elucidates underlying molecular mechanisms and offers a novel tool for predicting patient survival outcomes.
A newly isolated, safe gut bacterium, *Niallia circulans* YL01, effectively biodegrades L-homocysteine via remethylation and transsulfuration pathways, offering a promising microbial therapeutic strategy for treating hyperhomocysteinemia.
Early vitamin B12 treatment in SARS-CoV-2-infected hamsters mitigates long COVID-associated hippocampal neuroinflammation and neurodegeneration by preventing weight loss and suppressing CCL11 elevation, with sex-dependent effects on specific cellular alterations.
This study systematically compares four multicellular tumor spheroid fabrication platforms (U-bottom, ultra-low attachment, hanging drop, and droplet microfluidics), revealing that while they differ in fabrication efficiency and structural stability under dynamic conditions, these platform-dependent variations are critical factors to consider for reliable drug screening outcomes.