4605 papers
This study introduces a practical AlphaFold 3-based framework for the structural assessment of peptide-HLA class I complexes that corrects common immunoinformatics modeling errors by accurately reproducing key biological features and providing biologically meaningful insights beyond conventional affinity-based predictions.
This study identifies a large-scale supergene, characterized by a 1.75 Mbp inversion and translocation, that governs wing polymorphism in *Myrmecina nipponica* queens and likely evolved within and among *Myrmecina* species to mediate caste determination through transcriptional regulation of nutritional responses.
This study identifies a heterochronic expression pattern of TFAP2β, revealing that while its protein levels normally decline by term in mammalian models, they persist postnatally specifically within the obstructive shelf of coarctation of the aorta, offering a potential mechanistic insight into this congenital heart defect.
This genome-wide association study of 607 athletes of European ancestry failed to identify genome-wide significant genetic variants for anterior cruciate ligament rupture but highlighted several suggestive loci involved in inflammation, cellular stress, and ciliary function that warrant further investigation in larger cohorts.
This study reanalyzes single-cell transcriptomic data from human pancreatic islets to demonstrate that type 2 diabetes-associated signatures are subtle and compartment-specific, with immune-enriched signals like CXCL3 being best detected through donor-aware pseudobulk analysis rather than global or cell-level approaches.
This study demonstrates that attenuated *Salmonella* Typhimurium engineered to express bioactive interleukin-18 exerts potent antitumor effects against colorectal cancer by significantly reducing tumor cell viability and shifting the tumor microenvironment toward a pro-inflammatory, antitumor state.
This study demonstrates that while the CYP6P4-I236M mutation in *Anopheles gambiae* confers strong resistance to pyrethroid and PBO-based nets, it imposes significant fitness costs and reduced efficacy against chlorfenapyr-based nets, suggesting that rotation or mixture strategies with chlorfenapyr could effectively manage resistance.
This study reveals that the bigfin reef squid in the Mediterranean Sea comprises at least two distinct cryptic lineages of Red Sea origin, challenging the traditional view of *Sepioteuthis lessoniana* as a single species and highlighting the complexity of Lessepsian invasions.
This study developed and validated a highly specific and sensitive CRISPR/Cas12a-based detection system capable of accurately discriminating between the two genetically distinct *Plasmodium ovale* species (*P. wallikeri* and *P. curtisi*) in clinical samples, offering a promising tool for improved malaria diagnosis and surveillance.
This study documents the diversity, nesting ecology, and worker-level morphometric structure of stingless bees in Central Cameroon's bimodal forest zone, revealing that *Hypotrigona gribodoi* and *Dactylurina staudingeri* exhibit contrasting, size-structured phenotypic variations and distinct nesting habits while establishing the first locality-resolved baseline to support conservation and meliponiculture.