4605 papers
This study establishes and comprehensively characterizes a biobank of 40 living human kidney tubuloids derived from fresh and cryopreserved adult tissues, demonstrating their structural fidelity, molecular diversity, and compatibility with microfluidic systems to serve as a robust resource for drug screening, disease modeling, and precision medicine.
This study identifies adenylate cyclase 6 (Adcy6) as an evolutionarily conserved, essential regulator within both Schwann cells and neurons that drives timely peripheral nerve development, myelination, and ion channel clustering through cAMP signaling in vertebrates.
This study reports a novel AR c.2319-1G>T variant causing complete androgen insensitivity syndrome via exon 6 skipping, confirming through transcript analysis that canonical splice-site disruptions strongly correlate with this severe phenotype while highlighting limitations in relying solely on in silico prediction tools for non-substitution variants.
This study utilizes molecular docking simulations to demonstrate that while Roscovitine and Pifithrin-α exhibit strong predicted binding affinities to the CDK2 ATP-pocket with distinct interaction profiles, Nutlin-3 shows significantly weaker binding, suggesting Pifithrin-α warrants further investigation as a potential off-target binder within the p53 signaling pathway.
This study demonstrates that while conventional ratio scaling of peak oxygen uptake (VO₂peak) retains significant residual dependence on body mass, regression–residual normalization effectively eliminates this bias, offering a superior alternative to both ratio scaling and conventional allometric modeling for adjusting aerobic capacity across diverse body sizes.
This study demonstrates that trichloroethylene sensitization induces kidney injury in mice by upregulating β2 integrin, which triggers neutrophil activation and the release of neutrophil extracellular traps (NETs) via the PAD4 pathway.
The study identifies the *Acinetobacter baumannii* acyltransferase AimS as a critical factor in overcoming host nutritional immunity by repressing pili production and biofilm formation via the regulator CsuR, thereby conserving cellular ATP to maintain energy homeostasis and ensure bacterial fitness during respiratory infection.
This paper proposes a closed-loop Deep Brain Stimulation system that utilizes a network-based model of 60 brain regions as Hopf oscillators, combining a predictive detector with a two-level control strategy (linear-quadratic regulation and adjoint optimal control) to successfully pre-empt seizure-like bifurcations in 100% of simulations.
This study reveals that aging actively reprograms macrophages through coordinated shifts in epigenetics, metabolism, and function—characterized by reduced cytokine responsiveness, altered lipid metabolism, and phenotype-specific changes—rather than simply causing functional decline, thereby offering a new framework for understanding inflammaging and age-related diseases.
This study utilizes multi-state modeling to demonstrate that high baseline expression of proliferation-related genes is significantly associated with early recurrence and subsequent mortality in high-risk estrogen receptor-positive breast cancer, whereas late recurrence is linked to distinct signaling pathways.