1504 papers
This study benchmarks five Graph Neural Network architectures on 1,615 simulated tissue graphs undergoing T1 transitions, revealing that the Provably Powerful Graph Network (PPGN) achieves high accuracy with minimal data by employing a hybrid prediction strategy and highlighting tissue disorder as a key factor influencing model reliability.
This study introduces a functional depth analysis framework integrating spatial transcriptomics and network statistics to distinguish lung squamous cell carcinoma from adenocarcinoma by identifying subtype-specific pathway coordination architectures, mutation-driven rewiring, and microenvironment programming patterns that reveal novel mechanistic biomarkers for precision oncology.
This paper introduces "functional inertia" as a history-dependent, multilevel constraint on brain dynamics that structures activity into coherent regimes and explains how the same underlying mechanism can predict better cognitive performance in healthy individuals while driving greater symptom severity in schizophrenia, thereby reframing stability and volatility as context-dependent expressions of a single organizing principle.
This study utilized low-coverage sequencing and genome-wide association analysis on 536 Tianzhu White Yak individuals to identify 366 significant SNP loci and 32 candidate genes associated with key growth traits, providing valuable genetic markers to advance precision breeding programs.
This musculoskeletal modelling study reveals that both runner experience level and increased shoe longitudinal bending stiffness independently elevate Achilles tendon loading, with novice runners adapting to stiffer shoes through proximal compensations while experienced runners do not, supporting an individualized approach to optimal shoe stiffness.
This study comprehensively characterizes the wheat type II NAD(P)H dehydrogenase (TaND) gene family and identifies TaNDC1 as a positive regulator of Fusarium head blight resistance that interacts with the Fhb1 locus protein TaPFT.
This study demonstrates that magnolol protects rat nucleus pulposus cells from hydrogen peroxide-induced oxidative stress and senescence by preserving mitochondrial function and inhibiting apoptosis through the activation of the SIRT1/PGC-1α signaling pathway.
This study reveals that metronidazole concentrations in TYI-S-33 culture medium rapidly decline due to chemical interactions with iron-cysteine clusters rather than solely due to Giardia trophozoite uptake, a phenomenon that significantly alters the interpretation of drug efficacy in experimental settings.
This study identifies the endophytic bacterium *Proteus* sp. EKWG2I3 from the medicinal plant *Echinops kebericho* as a promising source of bioactive compounds, demonstrating significant *in vitro* antibacterial and antioxidant activities alongside the identification of methyl phenylacetate and pentanoic acid methyl ester as its major constituents via GC-MS profiling.
This study characterizes a population-enriched SETD1A missense variant (P596L) that increases bipolar disorder risk and causes cognitive deficits by inducing SETD1A hypofunction, which disrupts chromatin regulation, triggers replication stress, and impairs neurodevelopmental timing in a manner that can be partially rescued by pharmacologic inhibition of H3K4 demethylase KDM5.