3821 papers
This study demonstrates that the hepatic microcirculatory bed and parenchyma of piglets undergo a hierarchical transformation over the first 20 days after birth, evolving from an immature, non-oriented prenatal state into a mature, radially organized lobular structure through the coexistence of transitional architectures and the elimination of provisional features.
This study introduces a novel dual targeted/untargeted LC–MS/MS protocol to reveal that macroevolutionary conservation and ontogenetic optimization of aristolochic acid defenses in *Aristolochia* plants are driven by coevolutionary pressures from their specialist herbivore, the *Battus philenor* butterfly.
This global meta-analysis of 269 trials reveals that arbuscular mycorrhizal fungal inoculation generally promotes the expansion of root systems in non-woody plants by increasing surface area, length, and biomass, with these morphological responses being primarily driven by host plant family rather than fungal traits or environmental stress.
This study demonstrates that while behavioral data can constrain specific directions in the parameter space of whole-organism nervous system models, the vast majority of connectome-scale parameters remain undetermined, with the extent of identifiability depending on the diversity and functional demands of the elicited behaviors.
This study reveals that while body mass scales positively with basal metabolic rate in *Myotis velifer*, individual variation in metabolic rate is only weakly explained by body size, age, or reproductive status, suggesting that other intrinsic and ecological factors drive energy expenditure within maternity colonies.
This study challenges the dogma of microglia exclusivity by demonstrating that the brain-meningeal interface serves as a reservoir and entry site for peripheral macrophages, which can differentiate and migrate into the brain parenchyma to repopulate vacated niches, particularly in aging and neurodegenerative conditions.
This paper critiques the historical and political delays in updating AI architectures to reflect biological reality, arguing that the field's reliance on continuous voltage abstractions ignores critical ionic, glial, and retrograde mechanisms, and consequently proposes NIRGEN, a discrete, biophysically grounded Ionic Neural Network that overcomes the limitations of standard models by incorporating molecular conservation laws and enabling computations like XOR with single units.
This study demonstrates that in lumbar spinal stenosis, mechanical stress activates the Piezo1 ion channel to disrupt the blood–spinal cord barrier and trigger neuroinflammation via the FAK/RhoA/ROCK and CaMKII/NF-κB pathways, thereby driving neuropathic pain that can be alleviated by Piezo1 inhibition.
This study employs a leakage-safe machine learning consensus framework to identify 39 candidate SNPs associated with Border disease virus serostatus in goats, providing a hypothesis-generating genomic signal that warrants further functional validation.
This study demonstrates that the clinical behavior, therapeutic response, and resistance mechanisms in FLT3-mutant acute myeloid leukemia are determined by the topological architecture of gene interaction networks rather than individual mutations, with modular networks correlating to favorable outcomes and redundant, rewired networks driving resistance and relapse.