🧬 Category

q-bio

1504 papers

🧬 biology

Guarded LINCS/L1000 reversal of severe equine asthma recovers disease biology but no coherent non-steroidal reversal class

This study demonstrates that while severe equine asthma possesses a robust, cross-species-queryable transcriptomic signature, a guarded LINCS/L1000 computational reversal approach successfully filters out standard-of-care drugs but fails to identify a coherent class of non-steroidal therapeutic candidates, thereby validating the framework as a rigorous anti-circularity benchmark rather than a direct path to new drug nominations.

Cleverson de Souza2026-07-13
🧬 biology

Cross-Tissue WGCNA Reveals Conserved Brain-Blood Transcriptomic Signatures and Potential Biomarkers for Asymptomatic Alzheimer's Disease Diagnosis

This study developed a cross-tissue WGCNA pipeline anchored in the entorhinal cortex to identify a conserved five-gene transcriptomic signature in peripheral blood that effectively distinguishes asymptomatic Alzheimer's disease patients from healthy controls.

Efe Jennifer Jaiyeoba-Ojigho, Taye Motunrayo Ilesanmi, Chris-Ozoko Ebele Lilian, Oluwaseyi Abraham Olawale, Sefi Omole I (…)2026-07-12
🧬 biology

c-Myc promotes pulmonary fibrosis by driving myofibroblast activation and cellular senescence

This study demonstrates that c-Myc is significantly upregulated in idiopathic pulmonary fibrosis, where it acts as a critical pathogenic driver of myofibroblast activation and cellular senescence via the TGF-β1/Smad signaling pathway, suggesting that targeting c-Myc offers a promising therapeutic strategy for the disease.

Xiaomin Peng, Yuqi Mai, Ruijuan Guan, Hang Yin, Yinuo Wang, Hailin Liao, Jin Yu, Penghui Yang, Xu Chen2026-07-12
🧬 biology

Investigating the Effect and Mechanism of Semantic Alignment in Fixed-Backbone Protein Sequence Design

This study investigates the transferability and output-level effects of semantic alignment in protein sequence design by applying an AGSDD-inspired approach to MapDiff, finding that while it improves perplexity and increases semantic attention, it primarily acts as a distributional regularizer without significantly enhancing biochemical similarity or median recovery.

Ke Zhang2026-07-12
🧬 biology

Host Immune Endotype Determines IL-1β Dominance, Gut Barrier Failure, and Microbiota-Metabolite Circuit Rewiring During Combined Antibiotic and Colitis Injury: Implications for IBD Endotype-Tailored Therapy

This study demonstrates that host immune endotype dictates the outcome of combined antibiotic and colitis injury, where Th1-biased immunity drives IL-1β-dominated inflammation and metabolic dysregulation, while Th2-biased immunity promotes mucosal recovery through distinct anti-inflammatory metabolic circuits, highlighting the need for endotype-tailored therapies in IBD.

Sohini Mukhopadhyay, Kartika Sahu, Debopriya Saha, Palok Aich2026-07-11
🧬 biology

Enhanced Cytotoxicity of Liposomal Daunorubicin in HCT116 Colorectal Cancer Cells: Modulation of Oxidative Stress and ERK1/2 gene expression

This study demonstrates that liposomal daunorubicin exhibits superior cytotoxicity against HCT116 colorectal cancer cells compared to free daunorubicin by significantly enhancing oxidative stress, suppressing ERK1/2 gene expression, and inducing apoptotic morphological changes.

Fariba Moharami, Zahra Pourjam, Batool Shiri, Saja Abd Ali Shahadha, Mehdi Ebrahimi2026-07-10
🧬 biology

A Sampling-Based Computational Frame-work for Evaluating Enterotype Assignment Stability in Clinical Microbiome Studies

This study introduces a resampling framework demonstrating that enterotype assignments in clinical microbiome studies are often unstable and cohort-dependent, identifying a subset of "variable" individuals whose classifications fluctuate based on cohort composition while "core" individuals remain stable, thereby offering practical tools to determine when reliable four-enterotype stratification is feasible versus when simplified grouping is necessary.

Irene Creus-Martí, Jean-Daniel Zucker, Karine Clément, Edi Prifti, Eugeni Belda2026-07-10