1504 papers
By integrating whole-genome sequencing and single-cell RNA sequencing, this study reveals that ALS pathology arises from a multi-hit genetic architecture that converges on a stress-induced, inflammatory immune transcriptome characterized by the activation of innate lymphocyte populations.
This prospective neuroimaging study of 1,804 participants defines resilience as better-than-expected depressive outcomes relative to cumulative risk and reveals that while no immediate structural brain differences were found, higher resilience predicts a subsequent reduction in gray matter volume in the left inferior orbitofrontal gyrus and temporal pole, potentially reflecting neural efficiency or delayed biological costs.
This study identifies distinct CD146⁺ endothelial and pericyte populations that drive a repair-associated neovascularization program in rheumatoid arthritis pannus through specific transcriptional signatures and active intercellular communication.
The study introduces Nanomito, an amplification-free long-read nanopore sequencing workflow that outperforms routine PCR-based methods by providing accurate, full-length analysis of mitochondrial DNA, enabling reliable quantification of heteroplasmy and precise detection of large-scale deletions without amplification bias.
This paper proposes a multidimensional dynamical systems framework that represents conscious states as vectors comprising physical, cognitive, and noetic components to establish a shared mathematical language for mapping neuroelectromagnetic field dynamics to subjective experience and empirically comparing competing consciousness theories.
By combining transcript-to-genome alignments with alignment-free k-mer screening, this study demonstrates that sequence-detectable homologs of human lncRNAs are far more widespread across great ape genomes than previously recognized, revealing a substantial persistence of lncRNA-associated sequences despite their rapid evolution.
This study demonstrates that beta2* nicotinic acetylcholine receptors in the mouse prefrontal cortex regulate social and exploratory behaviors through functionally distinct neuronal populations, where knockdown in superficial-layer 5HT3a-expressing interneurons induces a robust hypersocial phenotype, while knockdown in mixed deep-layer neurons or striatal NPY-expressing cells produces opposing or milder effects, highlighting the necessity of cell-type-specific targeting for therapeutic interventions.
This study establishes a novel 3D spatial proteomics workflow to map the human pancreatic islet microenvironment at 50 µm resolution, revealing four distinct molecular zones including a previously underappreciated peri-islet niche, and provides an interactive platform for visualizing these spatial protein profiles to advance disease research.
This study presents a cultivar-resolved assembly and comprehensive characterization of the *Medicago sativa* cv. AH mitochondrial genome, revealing repeat-mediated structural isoforms, plastid-to-mitochondrion DNA transfers, extensive RNA editing landscapes, and intraspecific synteny rearrangements to advance understanding of cytoplasmic diversity in alfalfa.
While soil origin provides the diverse bacterial pool for legume-associated microbiomes, host plant identity acts as the primary filter that selectively recruits and structures these communities, resulting in distinct, host-specific bacterial assemblages.