3821 papers
This study reveals that hyaluronic acid synthesis is driven by an intramolecular energy metabolism where UDP hydrolysis regulates C-loop conformation to coordinate chain elongation and translocation, a mechanism shared by other polysaccharide synthases.
Picropodophyllotoxin (PPT) mitigates PM2.5-induced pulmonary injury in human pulmonary artery endothelial cells by alleviating oxidative stress and suppressing excessive autophagy through the activation of the mTOR signaling pathway.
This study integrates bioinformatics analysis with clinical validation to identify HBEGF and Th17-related markers (IL-17A, RORγt) as promising diagnostic biomarkers for Multiple Myeloma, highlighting their role in the disease's inflammatory microenvironment.
This study demonstrates that in Thai school-aged children, the C-G haplotype of TMPRSS6 polymorphisms rs855791 and rs2235324 is associated with a significantly reduced risk of iron deficiency compared to the T-A haplotype.
This study systematically maps the diverse biotransformation of 22 synthetic and natural steroids across 12 bacterial species, revealing novel enzymes, aerobic side-chain cleavage mechanisms, and cooperative cross-feeding interactions that collectively define the molecular basis of microbial steroid metabolism in gut and environmental ecosystems.
This study demonstrates that the transcription factor IRF4 suppresses myelodysplastic syndrome progression by transcriptionally activating CLIC4, which in turn intensifies apoptosis and inhibits proliferation in SKM-1 cells through the TGF-β/Smad and p38MAPK signaling pathways.
This study reveals that short-term memory in the posterior parietal cortex relies on a sparse temporal code anchored by a small subset of highly reliable neurons, whose precise spike timing is critical for maintaining information fidelity and guiding behavioral decisions beyond what firing rates alone can provide.
This study provides the first quantitative evidence that the emerging pathogen *Mycobacterium wolinskyi* forms a mature, stable, and EPS-rich biofilm under static in vitro conditions, with biomass significantly increasing over the first three weeks before plateauing by week six, thereby confirming its capacity for environmental persistence and device-associated infections.
This paper presents a clinically grounded, YOLO-based framework for the automated detection of sickled erythrocytes in peripheral blood smears, achieving high accuracy (mAP50-95 = 0.857) through optimized imaging and annotation strategies to enable scalable disease monitoring.
By employing nanopore-based genome skimming on 67 common vampire bats across nine Neotropical countries, this study reveals significant mitonuclear discordance driven by male-mediated gene flow, identifying Panama as a critical genetic corridor and the Andes as a major barrier that has shaped the species' evolutionary history and population structure.