🧬 Category

q-bio

1504 papers

🧬 biology

Spike Train Matching and Waveform Tracking Disagree: A Graph-Based Motor Unit Agreement Framework

This study challenges the long-held assumption that spike train matching and waveform tracking are interchangeable methods for identifying motor units across recordings, demonstrating through analysis of over 14,000 units that their agreement is highly dependent on dataset-specific characteristics and threshold selection, thereby necessitating dataset-specific calibration rather than universal thresholds.

Shiyu Zhang, Yue Wen, Mohsen Rakhshan2026-07-10
🧬 biology

Brain, blood, and cerebrospinal fluid vascular biomarkers reflect distinct biology in Parkinson's disease

This study demonstrates that vascular biomarkers derived from brain, blood, and cerebrospinal fluid in Parkinson's disease reflect distinct biological processes rather than interchangeable signals, challenging the assumption that these measures can be used interchangeably for biomarker validation.

Zohaib Atif, Uroos Akber, Daeun Roh, Hyoung-Ihl Kim, Hyuk-Sang Kwon, Chul-Seung Park2026-07-10
🧬 biology

Genome based subtyping identifies Parkinson’s disease subtypes with reproducible motor progression differences and clinical trial enrichment potential

This study demonstrates that genome-based subtyping of early Parkinson's disease identifies three reproducible clusters with distinct motor progression rates and clinical outcomes, offering a strategy to enrich clinical trial cohorts and significantly reduce required sample sizes.

Rafaela Ravazio, Daniel Teixeira-dos-Santos, Christian Mattjie, Alvaro de Oliveira Franco, Marco Antônio De Bastiani, An (…)2026-07-10
🧬 biology

Asymmetric Modulating Role of Action Magnitude in Hand-Action Sequence Effects

This study resolves conflicting findings on hand-action sequence effects by demonstrating that action magnitude drives an asymmetric pattern where precision actions inhibit subsequent power actions while power actions facilitate precision ones, a biomechanical hierarchy that overrides social cues and supports an integrated model of neural inhibitory mechanisms.

Min Hai, Xingfu Lei, Dengdeng Chen, Yonghui Wang2026-07-10
🧬 biology

Vegetation Community Composition and Species–Environment Relationships Along an Elevational Gradient in Sarpang District, Bhutan

This study of unmanaged broadleaved forests in Sarpang, Bhutan, reveals that while distinct forest types exhibit detectable but weak compositional differences across elevational gradients, the limited predictive power of environmental variables and regeneration models underscores the necessity for finer-scale microclimate and soil data to fully understand Himalayan forest community dynamics.

Wangdi Wangdi, Rupesh Subedi, Kezang Choden2026-07-10
🧬 biology

TMEM87A/EBP/7-DHC/7-DHD Axis Promotes Pancreatic Cancer Progression via Ferroptosis Evasion

This study reveals that KRAS upregulates TMEM87A to stabilize the cholesterol-biosynthetic enzyme EBP, thereby promoting the accumulation of anti-ferroptotic sterols (7-DHC and 7-DHD) and driving pancreatic cancer progression, which suggests that targeting this axis offers a promising therapeutic strategy for KRAS-mutant pancreatic ductal adenocarcinoma.

Jun Li, Shuqin Ouyang, Xuexin Yu, Yingru Xu, Ziwen Li, Yue Li, Jia Fei, Libing Song, Man Li2026-07-10
🧬 biology

Metabolomic Profiling and Putative Identification of Bioactive Compounds from Zymomonas mobilis Exhibiting Antibacterial and Antidiabetic Properties

This study demonstrates that *Zymomonas mobilis* strain ZM6 produces bioactive metabolites, including diketopiperazines and D-allose-rich fractions, which exhibit potent antibacterial activity against multidrug-resistant pathogens and enhance glucose uptake in insulin-resistant cells, despite the absence of canonical biosynthetic gene clusters in its genome.

Kozhir Karim Abdalla, Jun Ho Yim, Seong Seok Choi, Naz Kamaran Ahmed, Min Jae Kang, Yong Tae Jeong, Jae Sung Yun, Buyng (…)2026-07-10
🧬 biology

Quantum Kernel Methods for Calibrated and Interpretable Neuroimaging Classification in Computational Psychiatry

This paper demonstrates that a dual-pipeline framework utilizing quantum kernel support vector machines, combined with rigorous post-hoc calibration and interpretability techniques, significantly outperforms classical baselines in distinguishing psychiatric disorders using neuroimaging data while achieving high predictive accuracy and biological credibility.

Mouna Kettani, Fouad Mohammed Abbou, Farid Abdi, Fatima Zahra Zhiri, Khawla Ould Mansour2026-07-10
🧬 biology

Targeting PDAC Survival and Metastasis with Anacardium occidentale: Network Pharmacology and Structural Insights

This study utilizes an integrated network pharmacology and computational framework to identify carvacrol and pulegone from *Anacardium occidentale* as promising multi-target therapeutic candidates for pancreatic ductal adenocarcinoma, with carvacrol demonstrating superior thermodynamic stability and binding affinity against the MMP9 protein.

Anindita S Raju, Sadhana Balaji, Gayathri Chandren, Janaki Ramaiah Mekala2026-07-10