3821 papers
This study identifies and validates *pfcrt* gene copy number amplification as a previously unconsidered antimalarial resistance mechanism in *Plasmodium falciparum*, revealing its presence in outbreak strains from Sabah, Malaysia, and cases across the Philippines and West Africa.
This paper presents a generalized Bayesian statistical framework within Varlociraptor that unifies the detection of genetic variants and methylation rates across diverse sequencing platforms, enabling more accurate, uncertainty-aware, and joint analysis of genomic and epigenomic data.
This study demonstrates that a predictive neurobiomarker combining hippocampal and amygdalar mid-gamma spectral power and connectivity features derived from intracranial EEG during encoding can accurately estimate subsequent memory performance (R² = 0.8064), offering a potential basis for real-time cognitive rehabilitation systems.
Using a phylogenetic model based on IUCN data for over 5,000 species, this study identifies body mass and foraging stratum as key predictors of hunting vulnerability in terrestrial mammals, revealing that more than 450 currently unhunted species are at risk and mapping global hotspots to guide future conservation monitoring.
This study analyzes nearly 49,000 mature microRNA sequences across 271 organisms to reveal a widespread, lineage-associated positional organization characterized by significant depletion of CG and UA dinucleotides and enrichment of UG, suggesting structural or evolutionary constraints beyond simple mutational bias.
This study on Lagoa Misteriosa reveals that while phytoplankton blooms (WAB) and their absence (AAB) significantly influence the association of specific macroinvertebrate taxa and functional feeding groups with distinct water quality parameters, they do not alter the overall community structure or ecological indices.
This study identifies eight PSK family genes in tomato and demonstrates that SlPSK7 acts as a positive regulator of auxin signaling during fruit set by exhibiting expression patterns and regulatory effects on ARF genes that parallel auxin responses.
This study identifies DPP3 as a critical regulator of chemosensitivity in gastric cancer that promotes ferroptosis and restores therapeutic efficacy by destabilizing SLC3A2 to impair cystine uptake and glutathione synthesis.
This study reveals that astrocyte reactivity impairs bone marrow lymphopoiesis by inducing cholesterol accumulation in common lymphoid progenitors, which suppresses mTOR signaling and hinders B-cell development.
Contrary to the prevailing assumption that stress tolerance dictates survival in extraterrestrial environments, a large-scale genomic analysis of 3,531 archaeal genomes reveals that energy availability, particularly the exploitable energy density of methanogenesis, is the primary determinant of archaeal persistence across solar-system habitats.