1504 papers
This paper proposes the Host Energetic Allocation Model (HEAM), a deterministic biophysical framework demonstrating that epigenetic hysteresis traps myeloid cells in a high-metabolic state after viral clearance, thereby causing chronic neural energy depletion and explaining the pathophysiology of post-acute infection syndromes like Long COVID.
This study demonstrates that human umbilical cord mesenchymal stem cells (hUC-MSCs) effectively treat photoaged mouse skin and associated systemic organ damage by restoring mitochondrial autophagy, with combined local and tail-vein injection proving to be the most effective therapeutic strategy.
This study integrates bulk and single-cell transcriptomics to identify a seven-gene N4-acetylcytosine modification-related signature that effectively stratifies colorectal cancer patients into high- and low-risk groups while revealing distinct immune infiltration patterns, pathway enrichments, and key cellular differentiation trajectories to guide potential therapeutic strategies.
This study presents an integrated computational analysis of five approved DPP-4 inhibitors, revealing that sitagliptin and linagliptin exhibit the strongest predicted non-covalent binding affinities while highlighting methodological limitations in docking covalent inhibitors and providing a validated framework for future drug design.
PathwayBench introduces a comprehensive multi-criterion benchmark revealing that "rank-window competition" causes biological signal loss and direction inversion in rank-based pathway scoring methods, thereby guiding evidence-based method selection for pseudobulk single-cell RNA-seq analyses.
This study demonstrates that specific isolates of *Enterococcus faecium* and *Streptococcus bovis* from healthy human gut microbiota exhibit synergistic biofilm formation and significant antioxidant, iron-chelating, and anti-lipid peroxidation activities, highlighting their potential as probiotics for mitigating oxidative stress.
This study demonstrates that individuals with schizophrenia exhibit impaired adaptive executive control during ecologically valid tasks, characterized by elevated baseline frontal theta/beta ratios and reduced trial-level EEG modulation compared to healthy controls.
This hypothesis paper proposes that bacterial flagella serve as the primary effectors of viral and coinfection-driven carcinogenesis within the tumor microbiome by linking flagellar biology, complement evasion, and microbial dominance, and outlines five testable predictions plus a sixth extended hypothesis to guide future immuno-oncology research.
This paper proposes a unified phase-transition framework where chronic antigen exposure outcomes are governed by a tolerance stability index () and a dynamic "immune tide," predicting abrupt shifts between tolerance and effector states across diverse clinical conditions through critical bifurcation dynamics.
The Aiko–Takeru (AT) Model proposes a kidney-level flux–balance framework, derived from a longitudinal feline study with induced drainage asymmetry, suggesting that asymmetric polycystic kidney disease progression is driven by kidney-specific differences in drainage efficiency rather than systemic vasopressin exposure alone.