🛡️ immunology

The circ_0074371/miR-4738-3p/AMPK Signaling Axis Induces M1 Macrophage Polarization and Restricts Intracellular Survival of Mycobacterium tuberculosis

This study identifies the downregulated circRNA circ_0074371 as a diagnostic biomarker for active pulmonary tuberculosis that restricts *Mycobacterium tuberculosis* survival by acting as a competing endogenous RNA to sequester miR-4738-3p, thereby activating the AMPK signaling pathway to promote M1 macrophage polarization.

Original authors: Zhang, J.-a., Lian, C.-Y., Lu, Y.-B., Yao, S.-Y., Xu, H., Xu, Y., Liu, G.-B., Chen, G.-S., Cen, Y.-F., Li, Y.-T., Xu, Z.-L., Huang, Y.-D., Chen, G.-Y., Wang, J.-J., Shi, J.-H., Gao, Y.-C., Cai, X.-Z.

Published 2026-10-26

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CC BY 4.0

Original authors: Zhang, J.-a., Lian, C.-Y., Lu, Y.-B., Yao, S.-Y., Xu, H., Xu, Y., Liu, G.-B., Chen, G.-S., Cen, Y.-F., Li, Y.-T., Xu, Z.-L., Huang, Y.-D., Chen, G.-Y., Wang, J.-J., Shi, J.-H., Gao, Y.-C., Cai, X.-Z., Liang, J., Huang, W.-C., Zhang, Z.-P., Pi, J., Xu, J.-F.

Original paper licensed under CC BY 4.0 (https://creativecommons.org/licenses/by/4.0/). ⚕️ This is an AI-generated explanation of a preprint that has not been peer-reviewed. It is not medical advice. Do not make health decisions based on this content. Read full disclaimer

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