← Latest papers
📄 medicine

Surgical Management and Rehabilitation of Recurrent Central Giant Cells Granuloma (CGCG) of the jaw: a case report

This case report describes the successful long-term management of recurrent central giant cell granuloma in an 8-year-old patient through multiple surgical excisions followed by bone distraction rehabilitation, demonstrating that excellent aesthetic and functional outcomes are achievable despite extensive resections.

Original authors: Corrado Aversa, Maria Grazia Maglione, Massimo Mastroianni, Petra Claudia Camilla D’Orsi, Adimira Aversa, Massimiliano Amantea, Vladimiro Lanza

Published 2026-09-08
📖 4 min read☕ Coffee break read

Original authors: Corrado Aversa, Maria Grazia Maglione, Massimo Mastroianni, Petra Claudia Camilla D’Orsi, Adimira Aversa, Massimiliano Amantea, Vladimiro Lanza

Original paper licensed under CC BY 4.0 (https://creativecommons.org/licenses/by/4.0/). This is an AI-generated explanation of the paper below. It is not written or endorsed by the authors. For technical accuracy, refer to the original paper. Read full disclaimer

In the human body, bone is not merely a static scaffold; it is living tissue that constantly repairs itself and reshapes in response to stress. Occasionally, this repair mechanism goes awry, creating a benign but locally destructive growth known as a central giant cell granuloma. These lesions, while not cancerous, can act like a slow-moving erosion, eating away at the jawbone and displacing teeth. They appear most often in children and young adults, typically affecting the lower jaw. Because these growths can be aggressive, the standard medical approach has long been to surgically remove them. However, this solution presents a difficult dilemma: removing the growth often requires removing a significant portion of the jawbone, which can leave a young patient with a severe deformity, a loss of teeth, and a compromised ability to chew or speak. The medical community has therefore sought ways to treat the disease without sacrificing the patient's future quality of life, looking for methods that can restore what was lost rather than just cutting it away.

This story begins with an eight-year-old boy who arrived at a clinic in the year 2000 with a swelling in his lower gum. X-rays revealed a hole in his jawbone where several baby teeth should have been. The diagnosis was a central giant cell granuloma. The initial treatment was straightforward: the affected teeth were removed, and the remaining cavity was scraped clean. The tissue was examined under a microscope, confirming the diagnosis. Yet, over the following decade, the disease refused to stay gone. The boy experienced a relentless series of relapses, requiring nineteen separate surgical procedures to remove the recurring growths and scrape the bone clean each time. By the time he reached his late teens, the repeated surgeries had left his lower jaw severely thinned and shortened, a condition known as atrophy. The bone was simply too weak to support teeth or function properly, and the soft tissues had shrunk along with the bone.

The medical team faced a critical choice. They could leave the patient with a permanently altered face and jaw, or they could attempt a complex reconstruction. They chose the latter, employing a technique called bone distraction. This process involves a slow, controlled stretching of the bone. In this case, surgeons made precise cuts in the remaining jawbone and inserted a small mechanical device. Over the course of a month, the device was turned daily, pulling the two ends of the bone apart by half a millimeter each day. This gradual separation created a gap, and as the bone was stretched, the body's natural healing response filled that gap with new, solid bone. The device was left in place for a second month to allow this new bone to harden and consolidate.

Once the bone had grown to a sufficient height and strength, the device was removed. The surgeons then placed three titanium implants into the newly formed bone segment. These implants acted as artificial roots, waiting for the bone to fuse with them. After a few months of healing, a custom-made bridge was attached to these implants. This bridge was designed to look and feel natural, with a middle section that mimicked the pink color of healthy gums to replace the lost soft tissue, and a row of ceramic teeth to restore the ability to chew. The result was a jaw that looked whole and functioned normally.

The significance of this case lies not just in the successful surgery, but in the long-term outcome. The patient has now been followed for twenty-six years since his first diagnosis, and the disease has not returned. He is an adult with no visible deformities and has been fully integrated into society, able to eat and speak without difficulty. This case demonstrates that even after a decade of aggressive disease and multiple failed surgeries, it is possible to rebuild a jawbone and restore a patient's life. It suggests that while surgery remains the primary way to remove these stubborn growths, combining it with reconstructive techniques like bone distraction can overcome the severe damage left behind. The approach highlights that for young patients facing such a challenging condition, a multidisciplinary effort involving surgeons and reconstructive specialists can turn a history of repeated loss into a future of full function and appearance.

Drowning in papers in your field?

Get daily digests of the most novel papers matching your research keywords — with technical summaries, in your language.

Try Digest →