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Giant Fibroepithelial Stromal Polyp of the Vulva Mimicking a Malignant Neoplasm: A Rare Case Report

This case report describes a rare instance of a giant fibroepithelial stromal polyp of the vulva in a 29-year-old woman that clinically mimicked a malignant neoplasm due to its rapid growth and ulceration but was successfully treated with complete surgical excision and confirmed benign via histopathology.

Original authors: Moeen Hoseini, Somayeh Ghasemzadeh

Published 2026-09-20
📖 4 min read☕ Coffee break read

Original authors: Moeen Hoseini, Somayeh Ghasemzadeh

Original paper licensed under CC BY 4.0 (https://creativecommons.org/licenses/by/4.0/). This is an AI-generated explanation of the paper below. It is not written or endorsed by the authors. For technical accuracy, refer to the original paper. Read full disclaimer

In the human body, soft tissue growths can appear in many places, often causing alarm when they grow quickly or change shape. Most of these growths are benign, meaning they are not cancer and do not spread to other parts of the body, but their appearance can sometimes look frighteningly similar to malignant tumors. One such growth is a fibroepithelial polyp, a harmless lump made of connective tissue and skin that usually forms on mucosal surfaces like the vagina or cervix. While these are typically small and cause no trouble, they can occasionally grow to an enormous size, becoming what doctors call "giant" polyps. When this happens in a sensitive area like the vulva, the rapid expansion, pain, and ulceration can lead both patients and doctors to fear the worst, often suspecting a dangerous cancer. Understanding the difference between a benign overgrowth and a malignant tumor is critical, because the treatment for one is a simple removal, while the other might require aggressive, life-altering surgery.

This story centers on a specific case reported by researchers from Urmia University of Medical Sciences, involving a twenty-nine-year-old woman who arrived at a gynecology clinic with a startling discovery. She had noticed a mass on her right labia majora that had grown rapidly over the course of just one month. The lump was large, hanging from a stalk, and its surface was broken open, leaking a foul-smelling, pus-like fluid mixed with a little blood. These symptoms, combined with how fast it appeared, created a picture that strongly suggested a malignant neoplasm, or cancer. To understand what was happening inside the body without cutting into it first, the medical team used magnetic resonance imaging, a powerful scanning tool that creates detailed pictures of soft tissues. The scan revealed a massive, pedunculated growth measuring 9.4 by 6.4 by 4.6 centimeters. The images showed the mass was filled with blood vessels and had a bumpy, uneven texture, features that often raise red flags for cancer.

Despite the alarming size and the scary appearance of the wound on the surface, the medical team proceeded with a surgical plan focused on removing the entire growth. Under anesthesia, the surgeons carefully cut the mass away at its base where it attached to the body. During the procedure, they found two prominent blood vessels running through the stalk of the lump and tied them off to stop any bleeding. The entire specimen was then sent to a laboratory for a microscopic examination, which is the only way to know for sure what the tissue is made of. The wait for the final answer was twenty days, but the results were a relief. The pathologists found that the core of the mass was made of fibrous tissue and blood vessels, covered by a layer of normal skin cells. There were no signs of cancer cells, no abnormal shapes, and no evidence of a malignant tumor. The only unusual finding was a patch of dead tissue caused by bleeding, which the doctors determined happened because the stalk of the polyp had twisted on itself, cutting off its own blood supply. This twisting, known as torsion, explained the pain, the rapid swelling, and the discharge that had made the patient so worried.

The woman recovered well from the surgery, with the wound healing completely within a month. She reported that the pain she felt after the operation was manageable with standard pain medication and that she felt satisfied with the outcome. This case serves as a reminder that even when a growth looks terrifyingly large and aggressive, it can still be a benign condition. The researchers emphasize that while giant fibroepithelial polyps are extremely rare, they should be considered as a possibility when doctors see large, fast-growing masses in this area. By confirming the diagnosis through careful examination of the tissue, doctors can avoid unnecessary radical treatments and ensure that patients receive the right care. The story of this patient highlights how a combination of modern imaging, precise surgery, and careful laboratory analysis can turn a frightening medical mystery into a straightforward, curable condition.

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