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Notoginsenoside R1 Alleviates UVB Induced Skin Sunburn Injury by Targeting the NAT10/LRSAM1 Epitranscriptomic Axis Regulated by RNA N4-Acetylcytidine

Notoginsenoside R1 (NGR1) alleviates UVB-induced skin sunburn injury by upregulating the E3 ligase LRSAM1 to trigger the autophagic degradation of NAT10, thereby restoring ac4C homeostasis and enhancing the repair of UVB-induced DNA photoproducts.

Original authors: Wanqing Liu, Xiaoyue Zhou, Mengjie Tang, Dean Guo, Tao Yang, Tong Zhang, Zizhao Yang

Published 2026-10-12
📖 1 min read☕ Coffee break read

Original authors: Wanqing Liu, Xiaoyue Zhou, Mengjie Tang, Dean Guo, Tao Yang, Tong Zhang, Zizhao Yang

Original paper licensed under CC BY 4.0 (https://creativecommons.org/licenses/by/4.0/). ⚕️ This is an AI-generated explanation of a preprint that has not been peer-reviewed. It is not medical advice. Do not make health decisions based on this content. Read full disclaimer

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