🧬 biology
IFNα/IRF1-mediated NLRC5 aggravates autoimmunity by promoting the activation of plasmacytoid dendritic cells in Systemic Lupus Erythematosus
This study reveals that IFNα/IRF1-mediated epigenetic upregulation of NLRC5 drives plasmacytoid dendritic cell activation to exacerbate Systemic Lupus Erythematosus, a process that can be therapeutically targeted by tofacitinib.
Original paper licensed under CC BY 4.0 (https://creativecommons.org/licenses/by/4.0/). This is an AI-generated explanation of a preprint that has not been peer-reviewed. It is not medical advice. Do not make health decisions based on this content. Read full disclaimer
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