Single-cell sequencing-based elucidation of the molecular mechanisms by which the COVID-19 mRNA vaccine remodels the tumor microenvironment and sensitizes immune checkpoint inhibitors via the IFN-I pathway
This study utilizes multi-omics single-cell sequencing to elucidate how COVID-19 mRNA vaccines remodel the tumor microenvironment via a transient type I interferon response, thereby converting "cold" tumors to "hot" ones and sensitizing them to immune checkpoint inhibitors through a dual mechanism of immune recruitment and PD-L1 upregulation.
Original paper licensed under CC BY 4.0 (https://creativecommons.org/licenses/by/4.0/). This is an AI-generated explanation of a preprint that has not been peer-reviewed. It is not medical advice. Do not make health decisions based on this content. Read full disclaimer
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