Why Variance Metrics Cannot Validate ComBat Harmonization: Evidence from Three-Vendor Mammography Radiomics
This study demonstrates that conventional variance-based metrics provide a tautological and misleading validation of ComBat harmonization, as they fail to detect persistent non-linear vendor-specific patterns and biological signal loss, thereby necessitating the use of independent non-linear separability tests to truly assess cross-vendor comparability.
Original paper licensed under CC BY 4.0 (https://creativecommons.org/licenses/by/4.0/). This is an AI-generated explanation of the paper below. It is not written or endorsed by the authors. For technical accuracy, refer to the original paper. Read full disclaimer
Drowning in papers in your field?
Get daily digests of the most novel papers matching your research keywords — with technical summaries, in your language.