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The effects of Arf4 gene knockdown on Alzheimer's amyloid β deposition: Possible role in cognitive resilience

This study identifies ARF4 as a critical driver of cognitive resilience in aging, demonstrating that its knockdown exacerbates Alzheimer's pathology by increasing amyloid plaque burden and disrupting microglial homeostasis.

Original authors: Sara Hemmati, Erming Wang, Minghui Wang, Boer Xie, Stephen Salton, Vahram Haroutunian, David Bennett, Peng Xu, Junmin Peng, Sam Gandy, Bin Zhang, Michelle Ehrlich

Published 2026-10-14
📖 1 min read☕ Coffee break read

Original authors: Sara Hemmati, Erming Wang, Minghui Wang, Boer Xie, Stephen Salton, Vahram Haroutunian, David Bennett, Peng Xu, Junmin Peng, Sam Gandy, Bin Zhang, Michelle Ehrlich

Original paper licensed under CC BY 4.0 (https://creativecommons.org/licenses/by/4.0/). ⚕️ This is an AI-generated explanation of a preprint that has not been peer-reviewed. It is not medical advice. Do not make health decisions based on this content. Read full disclaimer

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