STAT3 of colonic epithelial cells prevents metabolic dysfunction-associated steatohepatitis by targeting Aldh1a1 to modulate gut-liver retinoic acids and CD103+ dendritic cells

This study reveals that colonic epithelial STAT3 prevents metabolic dysfunction-associated steatohepatitis (MASH) by directly suppressing Aldh1a1 transcription to regulate retinoic acid levels, thereby maintaining the gut-liver homeostasis of immunoregulatory CD103+ dendritic cells.

Original authors: Jiahui Xu, Jiyuan Zhou, Hongbin Liu, Ruo Huang, Wendi Zhang, Qian Zhou, Zhanhui Ye, Yangzhi Xu, Liangying Ye, Fachao Zhi, Hui Yang