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The COVID-19 RNA vaccine SpikevaxTM transfects human umbilical endothelial cells and induces Spike protein production, inflammation and leukocyte adhesion

This study demonstrates that the COVID-19 RNA vaccine Spikevax™ transfects human umbilical endothelial cells to produce Spike protein, which subsequently triggers the expression of proinflammatory cytokines and adhesion molecules, leading to increased leukocyte adhesion without compromising cell viability.

Original authors: Marco Cosentino, Marco Ferrari, Nicola Schiavone, Emanuela Rasini, Alessandra Luini, Massimiliano Legnaro, Maurizio Federico, Franca Marino, Giovanni Vanni Frajese

Published 2026-10-01
📖 1 min read☕ Coffee break read

Original authors: Marco Cosentino, Marco Ferrari, Nicola Schiavone, Emanuela Rasini, Alessandra Luini, Massimiliano Legnaro, Maurizio Federico, Franca Marino, Giovanni Vanni Frajese

Original paper licensed under CC BY 4.0 (https://creativecommons.org/licenses/by/4.0/). ✨ This is an AI-generated explanation of the paper below. It is not written or endorsed by the authors. For technical accuracy, refer to the original paper. Read full disclaimer

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