Targeting the p53–TFAM Axis to Overcome Exercise Intolerance in Long COVID
This study proposes that Long COVID-induced exercise intolerance stems from a viral-driven p53 degradation pathway that disrupts mitochondrial function via TFAM downregulation, and suggests that a host-directed p53/NRF2 epigenetic therapy can restore mitochondrial integrity and exercise capacity by reversing this bioenergetic collapse.
Original paper licensed under CC BY 4.0 (https://creativecommons.org/licenses/by/4.0/). This is an AI-generated explanation of a preprint that has not been peer-reviewed. It is not medical advice. Do not make health decisions based on this content. Read full disclaimer
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