📄 medicine

Sedentary Accumulation in Midlife and Subsequent SF-36 Physical Functioning and Pain Burden: A Longitudinal Analysis of the 1970 British Cohort Study

在对1970年英国队列研究的纵向分析中,在调整了总久坐时间和相关协变量后,中年时期累积的持续至少30分钟的长时段久坐时间比例,与51岁时的后续身体功能或疼痛负担之间并未表现出明确的相关性。

Renzheng Zuo, Yidan Wang, Deng Wang, Tian Hao, Jinlei Nie, Qingde Shi2026-09-08
📄 medicine

Associations between city-level urban sprawl and incident stomach disease among middle-aged and older Chinese adults: a prospective cohort study using the China Health and Retirement Longitudinal Study (CHARLS)

这项针对近万名中老年中国成年人的前瞻性队列研究表明,较高水平的城市扩张与自报胃部疾病发病率呈剂量反应性增加相关,凸显了城市形态对消化系统健康的潜在影响。

Zhiwen Wang, Xiao Jiang, Yujing Ye, Yu Lin2026-09-08
📄 medicine

Pure gonadal dysgenesis (46, XX type): A Case Report

本病例报告描述了一例诊断为纯性性腺发育不全(46,XX)的23岁女性,其表现为原发性闭经和高促性腺激素性性腺功能减退,强调了临床异质性带来的诊断挑战,以及及时进行激素替代治疗对于优化骨骼健康和心血管预后的至关重要性。

Arthur Brunelli Sales, Debora Rocha Barboza de Azevedo, Eduarda de Almeida Silva Drago, Lyvia do Prado Pacheco, Noemi Be (…)2026-09-08
📄 medicine

Cabozantinib reshapes the CD4+ T-cell exhaustion program in clear cell renal cell carcinoma through multi-target kinase inhibition and cytokine remodeling

本研究表明,卡博替尼通过抑制 AXL 并调节细胞因子信号传导,重编程了透明细胞肾细胞癌中耗竭的 CD4+ T 细胞,从而通过免疫重编程而非简单的效应功能恢复来重塑肿瘤免疫微环境。

Piotr Domanski, Małgorzata Stachowiak, Natalia Rusetska, Agnieszka Świć, Daniel Bajerski, Maciej Łuba, Sergiusz Markowic (…)2026-09-08
📄 medicine

Implementing the Big Catch-Up initiative in Mozambique: a qualitative assessment of implementation barriers, equity enablers, and lessons for routine immunization

这项针对莫桑比克“大追赶”(Big Catch-Up)倡议的定性研究表明,尽管强大的地区协调、社区参与和混合数据系统使得识别并为漏种儿童接种疫苗成为可能,但该计划的成功受到人力短缺和物流限制等系统性挑战的制约,凸显了在常规免疫系统中将情境适应型、以社区为导向的策略制度化的必要性,以维持公平性。

Jahit Sacarlal¹, Leonildo Nhampossa², Esmeralda Karajeanes³, Carlos Funzamo, Betuel Sigauque, Arlindo Banze², Ana Charle (…)2026-09-08
📄 medicine

Safety, quality of life, and efficiency of hospital at home admission compared with conventional hospitalization in acute heart failure A systematic review and meta-analysis

这项系统评价和荟萃分析表明,针对急诊科急性心力衰竭患者实施的直接“居家医院”收治,是与传统住院相比安全且临床等效的替代方案,并能显著降低30天再入院率并降低成本。

Maria Jose Fortuny, Pere Llorens, Begoña Espinosa, Carolina Sánchez, Harshida Patel, Vittoria Tibaldi, Trejeeve Martyn (…)2026-09-08