4086 papers
This study demonstrates that a synergistic triple-combination of thiol-reactive reagents (acrylamide, auranofin, and buthionine sulfoximine) effectively induces lethal oxidative stress and cell death in glioblastoma cells by disrupting redox signaling pathways while sparing primary neuronal cultures, offering a promising therapeutic strategy for treating glioblastoma.
This retrospective cohort study developed and externally validated a laboratory-free, nurse-assessable sepsis prediction model using XGBoost that demonstrated strong internal performance but poor external generalizability, suggesting that a simplified five-variable version may offer better cross-institutional transportability for emergency department triage despite requiring further prospective validation.
This cross-sectional study of Cameroonian healthcare workers reveals a high prevalence of musculoskeletal disorders, particularly in the lower back and neck, which are significantly associated with factors such as age, occupation, sedentary behavior, and poor physical health-related quality of life, while moderate physical activity serves as a protective factor.
This study establishes a rapid, scalable, and GMP-compatible 10-day manufacturing platform that generates highly specific, polyfunctional, and allogeneic virus-specific T cells with tissue-homing features and resident-memory-like plasticity, effectively overcoming precursor frequency limitations for treating refractory viral infections.
This 8-year retrospective cohort study of over 57,000 older adults in Shanghai reveals that while higher frequencies of health examinations are significantly associated with improved long-term trajectories for renal and hepatic function and LDL cholesterol, they are paradoxically linked to faster increases in BMI and triglycerides, suggesting that regular monitoring must be integrated with lifestyle interventions for comprehensive health promotion.
This prospective cohort study of 896 newborns in Ethiopia found that while post-discharge survival rates were high, the completion of the full postnatal care continuum remained low, with key predictors for care utilization including longer facility stays, maternal awareness of danger signs, and knowledge of follow-up timing.
This study identifies KIF24 as a critical oncogenic factor in gastric cancer that confers resistance to ferroptosis by maintaining Fe–S-dependent mitochondrial function, and demonstrates that its depletion triggers cell death via the AMPK/p53/SLC7A11 signaling axis, highlighting KIF24 as a promising therapeutic target.
This case report demonstrates that teprotumumab therapy in a patient with dysthyroid optic neuropathy led to significant clinical and electrophysiologic recovery, evidenced by the normalization of visual acuity and the reversal of delayed visual evoked potential latencies, supporting serial VEP assessment as an objective biomarker for treatment response.
This retrospective cohort study utilizing the MIMIC-IV database developed and internally validated a nomogram incorporating initial hyperlactatemia, age, blood urea nitrogen, and the paradoxical protective effect of diabetes to predict 28-day mortality in elderly hip fracture patients admitted to the ICU.
This cross-sectional study of 672 public schoolchildren in Bauru, Brazil, found a high prevalence of refractive errors (49.1%), with astigmatism being the most common type and a positive family history of spectacle use identified as the sole significant associated factor.