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Association Between Enamel Pearl Prevalence And Characteristics of on Cone Beam Computed Tomography With Supernumerary Teeth

This retrospective CBCT study of 12,874 teeth found a 0.05% prevalence of enamel pearls, which were significantly associated with molar tooth type and number but not gender, and notably showed no co-occurrence with supernumerary teeth.

Original authors: Amirhossein Aghajanzadeh, Nazmehr Vahdani Amoli, Seyedali Seyedmajidi, Ariana Rezaei Majd, Ehsan Moudi

Published 2026-10-22
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Original authors: Amirhossein Aghajanzadeh, Nazmehr Vahdani Amoli, Seyedali Seyedmajidi, Ariana Rezaei Majd, Ehsan Moudi

Original paper licensed under CC BY 4.0 (https://creativecommons.org/licenses/by/4.0/). ✨ This is an AI-generated explanation of the paper below. It is not written or endorsed by the authors. For technical accuracy, refer to the original paper. Read full disclaimer

Inside the complex architecture of a human mouth, teeth are not just uniform blocks of white; they are living structures with their own developmental quirks. Sometimes, during the formation of a tooth, a small, extra bump of enamel—the hard, protective outer layer—grows where it shouldn't. These are called enamel pearls. They typically appear on the roots of teeth, often near the neck where the crown meets the root, or in the forked areas where multi-rooted teeth split apart. While they might sound like a harmless curiosity, these tiny outgrowths can create hidden nooks where plaque accumulates, potentially leading to gum disease or even causing a tooth to shift position. Because these bumps are small and often tucked away in the complex geometry of the jaw, spotting them requires more than a standard flat X-ray; it demands a three-dimensional view to see the tooth from every angle.

A team of researchers in northern Iran set out to map the occurrence of these anomalies using a powerful imaging tool known as cone-beam computed tomography. This technology creates detailed, three-dimensional pictures of the teeth and jaws, allowing doctors to slice through the images digitally to inspect structures that would otherwise be hidden. The team analyzed the scans of 1,003 patients, examining a total of 12,874 individual teeth. Their goal was straightforward: to count how many of these enamel pearls existed in this specific population, to see exactly where they were hiding, and to check if they appeared more often in certain types of people or alongside other dental oddities, such as extra teeth.

The search yielded a rare find. Out of the nearly 13,000 teeth examined, the researchers identified only six instances of enamel pearls. This translates to a prevalence of roughly 0.05 percent, meaning these anomalies are quite uncommon in this group. When the team looked closer at the six cases, they found a clear pattern regarding location. Four of the pearls were nestled in the furcation areas—the V-shaped spaces between the roots of the molars—while the other two sat near the cervical region, closer to the gum line. This distribution is significant because the furcation areas are notoriously difficult to clean, making the presence of a pearl there a potential risk factor for periodontal health.

The study also investigated whether these pearls were linked to the patient's gender or the presence of supernumerary teeth, which are extra teeth beyond the normal set. The data showed no connection between gender and the occurrence of enamel pearls; the six cases were split evenly between men and women. Furthermore, the researchers found no evidence of extra teeth in any of the patients who had enamel pearls. This finding challenges a previous hypothesis from other studies that suggested a link between having extra teeth and developing enamel pearls. In this specific sample, the two conditions did not appear together.

Perhaps the most definitive discovery was the type of tooth involved. Every single one of the six enamel pearls was found on a molar, the large grinding teeth at the back of the mouth. Specifically, the second and third molars in the upper jaw were the most frequent locations. No pearls were found on the front teeth or the premolars. The researchers concluded that while enamel pearls are rare, their tendency to cluster on molars and in the hard-to-reach furcation zones makes them a critical detail for dentists to spot. Using three-dimensional imaging allows for the detection of these subtle structures, which could otherwise go unnoticed until they cause gum problems or interfere with the alignment of the teeth.

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