Different distribution of PDE4 isoforms in the central nervous system and muscle of the SOD1G93A mouse model of experimental amyotrophic lateral sclerosis during disease progression

This study reveals a complex, tissue-specific imbalance of PDE4 isoforms in the SOD1G93A mouse model of ALS, identifying specific upregulated isoforms (PDE4D8 and PDE4A11) as promising therapeutic targets while suggesting that the failure of previous pan-PDE4 inhibitors stems from the need for isoform-selective strategies rather than broad inhibition.