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Effectiveness of the culturally adapted version of Unplugged (“Yo Sé Lo Que Quiero”) among adolescents in Chile: results of a cluster randomized controlled trial.

This cluster randomized controlled trial in Chile found that the culturally adapted "Yo Sé Lo Que Quiero" program, while ineffective for reducing alcohol use among adolescents in economically vulnerable schools, significantly lowered tobacco and cannabis use, demonstrating the feasibility and selective efficacy of evidence-based prevention in Latin American settings.

Original authors: Jorge Gaete, Ramírez Saray, Valentina Romo, Ricardo Araya

Published 2026-07-21
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Original authors: Jorge Gaete, Ramírez Saray, Valentina Romo, Ricardo Araya

Original paper licensed under CC BY 4.0 (https://creativecommons.org/licenses/by/4.0/). This is an AI-generated explanation of the paper below. It is not written or endorsed by the authors. For technical accuracy, refer to the original paper. Read full disclaimer

Imagine a school not just as a place for math and history, but as a training ground for life's trickiest social situations. In the world of public health, scientists are constantly looking for the best "training manuals" to help teenagers navigate the pressure to try drugs and alcohol. For years, researchers have known that simply lecturing kids about the dangers of substances doesn't work very well; it's like telling a swimmer to stay dry while standing on the shore. Instead, the most successful programs act like a simulation game, teaching kids how to spot peer pressure, say "no" with confidence, and understand that their friends aren't actually doing the "cool" thing they think they are. This approach, often called the "Comprehensive Social Influence" model, has been tested in Europe and found to be a powerful shield. But here's the big question: does this shield work just as well in different parts of the world, specifically in schools where money is tight and challenges are high? That is the territory this study explores, asking if a program designed for one culture can be tweaked to protect kids in another without losing its superpowers.

In a massive experiment across 68 schools in Santiago, Chile, researchers tested a culturally adapted version of a famous European prevention program called "Unplugged." They renamed their version "Yo Sé Lo Que Quiero" (which translates to "I Know What I Want"). The goal was to see if this program could stop early teenagers from drinking alcohol, smoking tobacco, or using cannabis. The study involved over 9,000 students in 6th and 7th grade, splitting them into two groups: one that got the special 12-session course and one that just continued with their normal school routine. The researchers checked the students' habits right after the course finished and again four months later.

The results were a bit like a mixed bag of candy. When it came to the main target—alcohol use—the program didn't show a significant difference. Whether the students took the course or not, their drinking habits in the last 30 days remained pretty much the same. The authors suggest this might be because alcohol is so woven into the social fabric of Chilean life that a school program alone can't easily untangle it. However, the program did work like a charm for other substances. For tobacco and cannabis, the story changed. Students who went through the program were less likely to use these drugs later on. The effect was especially strong for the 7th graders; for them, the program cut the odds of using cannabis in the last month by nearly half compared to those who didn't take the course. It seems that hitting the program right when kids are getting older and facing more peer pressure (around 7th grade) might be the secret sauce.

Beyond just stopping drug use, the program successfully changed how the students thought about drugs. After the course, students had stronger negative beliefs about substances and felt more aware of the risks. They also felt less pressure to fit in by using drugs. Interestingly, the program was very well received; almost 80% of the students said it helped them understand the dangers, and they felt more capable of saying no in the future. The teachers and staff managed to deliver every single session with high quality, proving that even in schools with limited resources, a complex, interactive program can be run smoothly.

So, what's the takeaway? The study suggests that while this specific "social influence" training didn't stop the drinking tide in this specific context, it did successfully build a stronger defense against tobacco and cannabis, especially for older teenagers. It proves that you can take a proven prevention program from Europe, adapt it with local flavor, and run it effectively in Latin American schools. But it also hints that to stop alcohol use, we might need to bring in more than just the school—perhaps families and the wider community need to join the training session, too. The authors are careful to say this isn't a magic cure-all, but it is a promising step showing that with the right timing and cultural tweaks, we can help vulnerable teens make better choices.

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